青年脑梗死的TOAST分型及危险因素研究  

Analysis on the TOAST Subtypes and Risk Factors of Young Patients with Cerebral Infarction

作　　者：马静 李丹[1] 李晓鹏 王华[1] 张向红[1] MA Jing;LI Dan;LI Xiao-peng;WANG Hua;ZHANG Xiang-hong(Department of Neurology,The First Affiliated Hospital of Henan University,Kaifeng 475000,Henan Province,China)

机构地区：[1]河南大学第一附属医院神经科,河南开封475000

出　　处：《罕少疾病杂志》2025年第3期11-13,共3页Journal of Rare and Uncommon Diseases

基　　金：开封市科技攻关项目(2203040)。

摘　　要：目的 研究18~45岁的青年脑梗死的病因分型及其相关的危险因素。方法 搜集2022年1月至2022年12月在我院神经内科住院的18岁~45岁青年脑梗死患者91例,根据其发病机制确.定病因分型;分析不同病因分型的危险.因素。结果 本研究共纳.入91例青年脑梗死患.者,其中,男性69例,女性22例。根据TOAST分型,LAA型47例(516%),CE型10例(11%),SAO型3例(33%),ODC型12例(132%),UND型19例(.209%)。对不同病因分型的危险因素进行单因素卡方检验结果显.示,性别、吸烟、饮酒、高血压、CHOL↑、TG↑、LDL↑、高同型半胱氨酸血症(P<0.05)在青年脑梗死患者LAA型中有统计学意义;吸烟、高血压(P<005)在青年脑梗死患者CE型中有统计学意义;性别、吸烟、饮酒、C反应蛋白升高(P<005)在青年脑梗死患者ODC型中有统计学意义;CHOL↑、TG↑、LDL↑、高同型半胱氨酸血症、C反应蛋白升高在青年脑梗死患者UND型中有统计学意义。结论 青年脑梗死TOAST病因分型最常见的是LAA型,后依次为UND型、ODC型、CE型和SAO型。青年脑梗死不同病因分型的危险因素不同。Objective To explore the etiological subtypes and risk factors of young patients aged 18-45 with cerebral infarction.Methods Collect 91 young patients with cerebral infarction aged 18-45 who were hospitalized in the neurology department of our hospital from January 2022 to December 2022,and determine the etiological subtypes based on their pathogenesis.Results Among the 91 young patients with cerebral infarction in this study,69 were males and 22 were females.According to Toast classification,there were 47 cases(51.6%)of large artery atherosclerosis type,10 cases(11%)of cerebral embolism type,3 cases(3.3%)of small artery occlusion type,12 cases(13.2%)of stoke of other determined cause,and 19 cases(20.9%)of stoke of undetermined cause.The results of single factor chi square test on the risk factors of different etiological types showed that gender,smoking,drinking,hypertension,CHOL↑,TG↑,LDL↑,and hyperhomocysteinemia(P<0.05)have statistical significance in young patients with LAA type;Smoking and hypertension(P<0.05)have statistical significance in young patients with CE type;Gender,smoking,alcohol consumption,and elevated C-reactive protein levels(P<0.05)showed statistical significance in young patients with ODC type;CHOL↑,TG↑,LDL↑,hyperhomocysteinemia,and elevated C-reactive protein have statistical significance in young patients with UND type.Conclusions The most common etiological type of TOAST in young patients with cerebral infarction is LAA type,followed by UND type,ODC type,CE type,SAO type.The risk factors for different etiological subtypes of cerebral infarction in young people are different.

关 键 词：青年脑梗死 TOAST分型 危险因素 

分 类 号：R651.1[医药卫生—外科学]