糠酸莫米松鼻喷雾剂对慢性鼻窦炎鼻息肉术后鼻粘膜恢复及鼻黏膜组织中炎性因子水平的影响研究  

Effects of Mometasone Furoate Nasal Spray on the Recovery of Nasal Mucosa and Levels of Inflammatory Factors in Nasal Mucosa Tissues in Chronic Rhinosinusitis with Nasal Polyps

作　　者：孙盼盼 张学聪[1] 陈秉辉[1] 李少飞[1] SUN Pan-pan;ZHANG Xue-cong;CHEN Bing-hui;LI Shao-fei(Department of Otolaryngology,Head and Neck Surgery,Jiaozuo People's Hospital,Jiaozuo 454000,Henan Province,China)

机构地区：[1]焦作市人民医院耳鼻咽喉头颈外科,河南焦作454000

出　　处：《罕少疾病杂志》2025年第3期37-39,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的 探究鼻内镜术后糠酸莫米松鼻喷雾剂对慢性鼻窦炎鼻息肉术后鼻粘膜恢复及血清中炎性因子水平的影响。方法 将2020年2月至2023年2月于我院接受鼻内镜手术治疗的103例慢性鼻窦炎鼻息肉患者纳入研究。将接受鼻内镜术后常规治疗的患者纳入常规组(52例),将接受糠酸莫米松鼻喷雾剂治疗的患者纳入研究组(51例),治疗周期为4周。对比两组患者治疗有效率;治疗前、治疗2周后及治疗4周后的嗅觉功能评分;鼻粘膜恢复情况[糖精清除时间(SCT)、鼻黏液纤毛清除率(MTR)、黏液纤毛清除速率(MCT)水平];血清中炎性因子[肿瘤坏死因子.-α(TNF-α)、C蛋白反应(CRP)、白介素-6(IL-6)]水平及术后并发症(鼻腔干燥.、鼻腔粘连、窦口闭塞)的发生情况。结果 研究组治疗有效率高于常规.组(P<005);研究组患者治疗2周后和治疗4周后的嗅觉.功能评分均低于常规组(P<005);研究组SCT水平.低于常规组,MTR、MCT水平均高于常规组(P<005);研究组TNF-α、CRP、IL-6水平均低于常规组(P<005);研究组术后并发症发生率低于常规组(P<005)。结论 糠酸莫米松鼻喷雾,能够有效缓解慢性鼻窦炎术后患者临床症状、改善嗅觉功能、加快鼻黏膜的恢复速度以及降低血清中的炎性因子水平和术后并发症发生率。Objective To explore the effects of mometasone furoate nasal spray on the recovery of nasal mucosa and levels of inflammatory factors in serum in chronic rhinosinusitis with nasal polyps after nasal endoscopy.Methods A total of 103 patients with chronic rhinosinusitis and nasal polyps who underwent nasal endoscopy in the hospital were enrolled between February 2020 and February 2023.They were divided into routine group(52 cases,routine treatment)and study group(51 cases,mometasone furoate nasal spray).All were treated for 4 weeks.The response rates of treatment,scores of olfactory function before treatment,after 2 weeks and 4 weeks of treatment,recovery of nasal mucosa[saccharin clearance time(SCT),mucociliary transport rate(MTR),mucociliary clearance time(MCT)],levels of inflammatory factors[tumor necrosis factor-α(TNF-α),C-protein response(CRP),interleukin-6(IL-6)]in serum and the occurrence of postoperative complications(nasal dryness,nasal adhesion,sinus occlusion)in the two groups were compared.Results The response rate of treatment in study group was higher than that in routine group(P<0.05).After 2 weeks and 4 weeks of treatment,scores of olfactory function in study group were lower than those in routine group(P<0.05).SCT level in study group was lower than that in routine group,while MTR and MCT were higher than those in routine group(P<0.05).The levels of TNF-α,CRP and IL-6 in study group were lower than those in routine group(P<0.05).The incidence of postoperative complications in study group was lower than that in routine group(P<0.05).Conclusion Mometasone furoate aqueous nasal spray can effectively relieve the clinical symptoms of patients with chronic sinusitis after operation,improve the olfactory function,accelerate the recovery of nasal mucosa,and reduce the level of inflammatory factors in serum and the incidence of postoperative complications.

关 键 词：糠酸莫米松鼻喷雾剂 慢性鼻窦炎鼻息肉 鼻粘膜恢复 炎性因子 

分 类 号：R765.41[医药卫生—耳鼻咽喉科]