常规多动症药物联合多巴胺受体激动剂对小儿多动症的治疗效果评价  

Evaluation of the Therapeutic Effect of Conventional ADHD Drugs Combined with Dopamine Receptor Agonists on Pediatric ADHD

作　　者：王彬彬 张晋雷[1] 杨英阁[1] WANG Bin-bin;ZHANG Jin-lei;YANG Ying-ge(Department of Pediatrics,The First Affiliated Hospital of Nanyang Medical College,Nanyang 473000,Henan Province,China)

机构地区：[1]南阳医学高等专科学校第一附属医院儿科,河南南阳473000

出　　处：《罕少疾病杂志》2025年第3期162-164,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的 探讨常规多动症药物盐酸哌甲酯联合多巴胺受体激动剂吡贝地尔缓释片对小儿多动症(ADHD)的治疗效果。方法 选取南阳医学高等专科学校第一附属医院收治的80例小儿ADHD患者,选取时间为2020年7月至2022年7月,按照治疗方法分为参照组40例与观察组40例。参照组仅采用常规多动症药物盐酸哌甲酯控释片治疗,观察组采用多巴胺受体激动剂吡贝地尔缓释片进行联合治疗。比较两组治疗效果。结果 (1)观察组临床疗效显著优于参照组(P<0.05);(2)两组患儿治疗后Conners'儿童量表各维度(身心问题、品行问题、冲动多动、学习问题)评分较治疗前均显著下降(P均<0.05),且观察组患儿治疗后Conners'儿童量表各维度评分更低(P均<0.05);(3)两组患儿治疗后多巴胺水平较治疗前均显著高于治疗前,且观察组治疗后多巴胺水平更高(P均<0.05);(4)两组不良反应发生率无显著的统计学差异(P>0.05)。结论常规多动症药物盐酸哌甲酯联合多巴胺受体激动剂吡贝地尔缓释片对小儿ADHD的治疗效果显著,改善患儿行为,应在临床加以推广及应用。Objective To explore the therapeutic effect of the combination of conventional ADHD drug methylphenidate hydrochloride and dopamine receptor agonist pirbedil sustained-release tablets on attention deficit hyperactivity disorders(ADHD)in children.Methods According to the treatment methods,from July 2020 to July 2022,80 cases of the pediatric ADHD patients admitted to the First Affiliated Hospital of Nanyang Medical College were selected and divided into the reference group(n=40)and the observation group(n=40).The reference group was only treated with conventional ADHD drug methylphenidate hydrochloride referenceled-release tablets,while the observation group was treated with a combination of dopamine receptor agonist Pirbedil sustained-release tablets on this basis.The therapeutic effects of the two groups were compared.Results(1)The clinical efficacy of the observation group was significantly better than reference group(P<0.05);(2)after treatment,the scores of all dimensions of the Conners'Children's Scale(physical and mental problems,conduct problems,impulsivity,and learning problems)in both groups of children significantly decreased compared to before treatment(P<0.05),and the scores of all dimensions of the Conners'Children's Scale in the observation group were significantly lower than reference group after treatment(P<0.05).(3)The dopamine levels in both groups of children after treatment were significantly higher than before treatment,and the dopamine levels in the observation group were significantly higher than reference group after treatment(P<0.05).There was no significant statistical difference in the incidence of adverse reactions(P>0.05).Conclusions The combination of conventional ADHD drug methylphenidate hydrochloride and dopamine receptor agonist pembriae sustained-release tablets has a significant therapeutic effect on pediatric ADHD and improves their behavior.It should be promoted and applied in clinical practice.

关 键 词：小儿多动症 多巴胺受体激动剂 多巴胺 Conners儿童行为量表 

分 类 号：R272.6[医药卫生—中医儿科学]