Impaired tactile processing in autism-associated Shank3 mutant dogs:neural mechanism and intervention  

孤独症相关Shank3突变犬触觉敏感性降低的神经机制和干预

作　　者：Qi Shi Liang Wu Baolong Ren Kun Guo Yong-Hui Jiang Yong Q.Zhang Li Hu 史奇;吴梁;任宝龙;郭昆;姜永辉;张永清;胡理

机构地区：[1]State Key Laboratory for Molecular and Developmental Biology,Institute of Genetics and Developmental Biology,Chinese Academy of Sciences,Beijing 100101,China [2]College of Life Sciences,University of Chinese Academy of Sciences,Beijing 100049,China [3]Sino-Danish College,University of Chinese Academy of Sciences,Beijing 100049,China [4]School of Psychology,University of Lincoln,Brayford Pool,Lincoln LN67TS,UK [5]Department of Genetics,Yale University School of Medicine,New Haven,CT 06510,USA [6]Department of Neuroscience,Yale University School of Medicine,New Haven,CT 06510,USA [7]Department of Pediatrics,Yale University School of Medicine,New Haven,CT 06510,USA [8]School of Life Sciences,Hubei University,Wuhan 430415,China [9]CAS Key Laboratory of Mental Health,Institute of Psychology,Chinese Academy of Sciences,Beijing 100101,China [10]Department of Psychology,University of Chinese Academy of Sciences,Beijing 100049,China

出　　处：《Science Bulletin》2025年第4期483-487,共5页科学通报(英文版)

基　　金：supported by the National Key Research and Development Program(2019YFA0707100 and 2021ZD0203901);the National Natural Science Foundation of China(31830036,31921002,and 32071061);the Beijing Natural Science Foundation(JQ22018);the Spring City Plan(2022SCP001).

摘　　要：Sensory processing anomaly is a common co-morbidity associated with Autism Spectrum Disorder(ASD).While the prevalence of altered sensory responses is reported in up to 90%of ASD individuals[1],sensory processing abnormalities exhibit considerable heterogeneity of either heightened or reduced reactivity to various stimuli,including tactile[2].Despite the significance of sensory issues,the cause and pathophysiology underlying sensory abnormalities in ASD individuals remain largely unknown.Mutations in SHANK3 are one of the most common genetic causes of ASD.Besides highly penetrant autism core behaviors,sensory processing issues are reported commonly in individuals with SHANK3 genetic mutations.

关 键 词：neural SPITE PROCESSING 

分 类 号：R54[医药卫生—心血管疾病]