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作 者:Lina Kang Jingyi Sheng Xue Bao Guozhen He Liang Mao Qiang Wang Jianrong Lu Min Zhou Yepeng Zhang Ling He Yuqin Guo Xiang Guan Zhipeng Wu Xuguang Jin Biao Xu Ning Gu 康丽娜;盛静逸;鲍雪;何国桢;毛谅;王强;陆剑嵘;周敏;张业鹏;贺玲;郭玉琴;管翔;吴志鹏;金旭光;徐标;顾宁
机构地区:[1]Nanjing Key Laboratory for Cardiovascular Information and Health Engineering Medicine,Institute of Clinical Medicine,Cardiovascular Medical Center,Nanjing Drum Tower Hospital,Medical School,Nanjing University,Nanjing 210093,China [2]Jiangsu Key Laboratory for Biomaterials and Devices,School of Biological Science and Medical Engineering,Southeast University,Nanjing 210009,China [3]Department of Pancreatic and Metabolic Surgery,Nanjing Drum Tower Hospital,Affiliated Hospital of Medical School,Nanjing University,Nanjing 210008,China [4]Department of Intensive Care Unit,Nanjing Drum Tower Hospital,Affiliated Hospital of Medical School,Nanjing University,Nanjing 210008,China [5]Cardiac Surgery,The Second Affiliated Hospital of Nanjing Medical University,Nanjing 210003,China
出 处:《Science Bulletin》2025年第4期488-491,共4页科学通报(英文版)
基 金:supported by the Major Scientific and Technological Infrastructure Cultivation Projects of Jiangsu Province,China,the National Natural Science Foundation of China(61821002);the Natural Science Foundation of Jiangsu Province(BK20222002);Jiangsu Provincial Medical Key Discipline(ZDXK202208).
摘 要:Human body exemplifies one of the most intricate and sophisticated systems,characterized by nonlinear interactions of numerous components[1].Advances in science and technology have greatly enhanced our understanding of life at the microscopic level,elucidating numerous biological phenomena at the cellular,molecular and even atomic scales[2],[3],[4].Nevertheless,challenges persist in comprehending biological system at macroscopic levels,particularly regarding the integrative interactions among multiple organs and systems within the human body.Cutting-edge research has underscored the coordinated roles of different organs and systems in both physiological functions and diseases,with growing evidence of interactions such as heart-brain connections[5],[6],neuro-immune interactions[7],[8],and other inter-organ/system interactions[9],[10].In this context,studying the functions of individual cells,tissues,or organs in isolation does not adequately capture the dynamic and comprehensive nature of life’s processes.Therefore,addressing key questions in life sciences requires approaches that account for system-wide integrity and complexity.
关 键 词:SYSTEM COORDINATED ORGANS
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