New perspectives on microbiome-dependent gut-brain pathways for the treatment of depression with gastrointestinal symptoms:from bench to bedside  

作　　者：Menglin LIU Genhao FAN Lingkai MENG Kuo YANG Huayi LIU 

机构地区：[1]The First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Brain Disease Regional Diagnosis and Treatment Center,Zhengzhou 450000,China [2]Tianjin University of Traditional Chinese Medicine,Tianjin 301600,China [3]Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital,Tianjin 300131,China [4]The First Affiliated Hospital of Zhengzhou University,Department of Geriatrics,Zhengzhou 450052,China

出　　处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2025年第1期1-25,共25页浙江大学学报(英文版)B辑(生物医学与生物技术)

基　　金：supported by the First Affiliated Hospital of Henan University of Traditional Chinese Medicine(Zhengzhou,China);the Scientific Research Projects in Key Areas of Traditional Chinese Medicine of Tianjin Municipal Health and Health Commission(No.2023004),China.

摘　　要：Patients with depression are more likely to have chronic gastrointestinal(GI)symptoms than the general population,but such symptoms are considered only somatic symptoms of depression and lack special attention.There is a chronic lack of appropriate diagnosis and effective treatment for patients with depression accompanied by GI symptoms,and studying the association between depression and GI disorders(GIDs)is extremely important for clinical management.There is growing evidence that depression is closely related to the microbiota present in the GI tract,and the microbiota-gut-brain axis(MGBA)is creating a new perspective on the association between depression and GIDs.Identifying and treating GIDs would provide a key opportunity to prevent episodes of depression and may also improve the outcome of refractory depression.Current studies on depression and the microbially related gut-brain axis(GBA)lack a focus on GI function.In this review,we combine preclinical and clinical evidence to summarize the roles of the microbially regulated GBA in emotions and GI function,and summarize potential therapeutic strategies to provide a reference for the study of the pathomechanism and treatment of depression in combination with GI symptoms.

关 键 词：DEPRESSION Gastrointestinal disorders Gut-brain axis PATHOMECHANISM TREATMENT 

分 类 号：R74[医药卫生—神经病学与精神病学]