A soft,ultra-tough and multifunctional artificial muscle for volumetric muscle loss treatment  

作　　者：Peng-Fei Qiu Lei Qiang Weiqing Kong Fang-Zhou Wang Hong-Qin Wang Ke-Xin Hou Yihao Liu Cheng-Hui Li Pengfei Zheng 

机构地区：[1]State Key Laboratory of Coordination Chemistry,School of Chemistry and Chemical Engineering,Collaborative Innovation Center of Advanced Microstructures,Nanjing University,Nanjing 210023,China [2]Department of Orthopaedic Surgery,Children’s Hospital of Nanjing Medical University,Nanjing 210004,China [3]Department of Orthopedic Surgery,Xuzhou Central Hospital,Xuzhou Clinical School of Xuzhou Medical University,Xuzhou 221009,China [4]Shanghai Key Laboratory of Orthopedic Implant,Department of Orthopedic Surgery,Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200011,China

出　　处：《National Science Review》2025年第2期224-237,共14页国家科学评论(英文版)

基　　金：supported by the National Natural Science Foun-dation of China(22271139 and 22425106);the Fundamental Research Funds for the Central Universities(020514380294).

摘　　要：The escalating prevalence of skeletal muscle disorders highlights the critical need for innovative treatments for severe injuries such as volumetric muscle loss.Traditional treatments,such as autologous transplants,are constrained by limited availability and current scaffolds often fail to meet complex clinical needs.This study introduces a new approach to volumetric muscle loss treatment by using a shape-memory polymer(SMP)based on block copolymers of perfluoropolyether and polycaprolactone diol.This SMP mimics the biomechanical properties of natural muscle,exhibiting a low elastic modulus(2-6 MPa),high tensile strength(72.67±3.19 MPa),exceptional toughness(742.02±23.98 MJ m^(-3))and superior biocompatibility,thereby enhancing skeletal muscle tissue integration and regeneration within 4 weeks.Moreover,the polymer’s shape-memory behavior and ability to lift>5000 times its weight showcase significant potential in both severe muscle disorder treatment and prosthetic applications,surpassing existing scaffold technologies.This advancement marks a pivotal step in the development of artificial muscles for clinical use.

关 键 词：volumetric muscle loss scaffolds shape-memory polymer skeletal muscle stimuli responsiveness 

分 类 号：O63[理学—高分子化学]