2型糖尿病患者常见慢性病共存状态模式的现况研究  

A cross-sectional study of common comorbidity patterns in patients with type 2 diabetes mellitus

作　　者：高宁 盛丹 唐绍琰 王敏珍[1] GAO Ning;SHENG Dan;TANG Shaoyan;WANG Minzhen(Institution of Epidemiology and Health Statistics,School of Public Health,Lanzhou University,Lanzhou 730000,China)

机构地区：[1]兰州大学公共卫生学院流行病与卫生统计学研究所,兰州730000

出　　处：《中华疾病控制杂志》2025年第2期152-157,163,共7页Chinese Journal of Disease Control & Prevention

基　　金：甘肃省杰出青年基金(23JRRA1019);河北省糖尿病基础医学研究重点实验室开放课题(KF2023-02)。

摘　　要：目的 探讨2型糖尿病患者共患病情况及其慢性病共存状态(简称共病)模式,为2型糖尿病患者的共病管理提供数据支持。方法 以金昌队列2011年6月―2013年12月基线调查中的3 592例2型糖尿病患者为研究对象,结合流行病学调查、体格检查和临床生化的资料,纳入患病率>5%的18种慢性病,分析2型糖尿病患者的共患病现状。采用Apriori算法探索常见共病模式,并通过网络图、分组矩阵图和平行坐标图对结果进行可视化。结果 在金昌队列研究中,2型糖尿病患者共病率为98.58%(3 541/3 592),以2~4种共病为主。单病种排序前3位的疾病分别为高脂血症(78.29%)、高血压(63.20%)和脂肪肝(46.97%)。2型糖尿病患者最常见的二元、三元和四元共病模式分别为:高血压和高脂血症,高血压、高脂血症和脂肪肝,以及心律失常、脂肪肝、高脂血症和高血压。不同性别和年龄段的共病模式存在差异。结论 金昌队列2型糖尿病患者普遍存在共病现象,高脂血症、高血压和脂肪肝是共病模式的核心疾病,应加强2型糖尿病患者中这3种慢性病的筛查和预防。Objective To investigate the comorbidity conditions and patterns among patients with type 2 diabetes mellitus,and to provide data support for the management of comorbidities in these patients.Methods The participants of the present study included 3592 patients with type 2 diabetes from the Jinchang cohort,based on baseline surveys conducted from June 2011 to December 2013.By combining data from epidemiological investigations,physical examinations,and clinical biochemical tests,our study included 18 chronic diseases with prevalence rates greater than 5%,and the comorbidity status of patients with type 2 diabetes were analyzed.The Apriori algorithm was used to explore common comorbidity patterns,and the results were visualized through network diagrams,grouped matrix plots,and parallel coordinate plots.Results The comorbidity rate among the Jinchang cohort patients with type 2 diabetes was as high as 98.58%(3541/3592),primarily involving 2-4 comorbidities.The top three individual diseases were hyperlipidemia(78.29%),hypertension(63.20%),and fatty liver(46.97%).The most common binary,ternary,and quaternary comorbidity patterns were hypertension and hyperlipidemia,followed by hypertension and hyperlipidemia and fatty liver,and finally arrhythmia and fatty liver and hyperlipidemia and hypertension,respectively.Differences in comorbidity patterns were observed across different genders and age groups.Conclusions Comorbidity is a common phenomenon among patients with type 2 diabetes in the Jinchang cohort,with hyperlipidemia,hypertension,and fatty liver being the core diseases in these patterns.There should be an emphasis on screening and prevention of these three chronic diseases among patients with type 2 diabetes.

关 键 词：2型糖尿病 慢性病 共病模式 现况研究 

分 类 号：R181.3[医药卫生—流行病学]