发热伴血小板减少综合征高发地区人群血清抗体流行状况及感染危险因素  

Analysis of neutralizing activity of antibody in serum and its influencing factors in natural population in high incidence areas of severe fever with thrombocytopenia syndrome in Anhui Province

作　　者：龚磊[1] 陈晴晴 汪金生[2] 徐鹏鹏[3] 程东林 刘旭祥[5] 杨锟[6] 孙永[1] 储娜 吴家兵[1] GONG Lei;CHEN Qingqing;WANG Jinsheng;XU Pengpeng;CHENG Donglin;LIU Xuxiang;YANG Kun;SUN Yong;CHU Na;WU Jiabing(Anhui Provincial Center for Disease Control and Prevention,Hefei 230601,China;Anqing Municipal Center for Disease Control and Prevention,Anqing 246005,China;Lu′an Municipal Center for Disease Control and Prevention,Lu′an 237010,China;Chuzhou Municipal Center for Disease Control and Prevention,Chuzhou 239099,China;Hefei Municipal Center for Disease Control and Prevention,Hefei 230022,China;Maanshan Municipal Center for Disease Control and Prevention,Maanshan 243011,China)

机构地区：[1]安徽省疾病预防控制中心,合肥230601 [2]安庆市疾病预防控制中心,安庆246005 [3]六安市疾病预防控制中心,六安237010 [4]滁州市疾病预防控制中心,滁州239099 [5]合肥市疾病预防控制中心,合肥230022 [6]马鞍山市疾病预防控制中心,马鞍山243011

出　　处：《中华疾病控制杂志》2025年第2期211-216,共6页Chinese Journal of Disease Control & Prevention

基　　金：国家疾病预防控制局公共卫生人才培养支持项目;安徽医科大学公共卫生学院协同育人创新项目(2024GWXTYRZ002)。

摘　　要：目的 了解安徽省发热伴血小板减少综合征(severe fever with thrombocytopenia syndrome, SFTS)高发地区自然人群血清免疫球蛋白G(immunoglobulin G, IgG)抗体的流行状况及感染的影响因素,为SFTS防控工作提供依据。方法 收集2021年SFTS高发地区自然人群血清样本及流行病学资料,根据抗体检测结果分为IgG抗体阴性组和阳性组,分析两组在一般人口资料、既往健康状况、环境暴露情况、媒介暴露情况的差异,采用χ^(2)/Z检验进行单因素分析,针对两组资料在单因素分析基础上进行多因素logistic回归分析。结果 本研究共纳入安徽省SFTS高发地区自然人群1 255例,其中IgG抗体阳性组174例(13.86%)。单因素分析结果显示,两组人群在一般人口资料(村类别和年龄)方面的差异有统计学意义(均P<0.05);在既往健康状况方面,两组人群在曾经是否诊断为SFTS方面的差异均有统计学意义(χ^(2)=13.678,P<0.05);在环境暴露情况方面,两组人群在从事农业生产、被蜱虫叮咬过、住宅周围环境有杂草生长、住宅周围见过蜱虫、经常野外工作等方面的差异均有统计学意义(均P<0.05);在媒介暴露情况方面,两组人群在是否在鼠洞附近坐卧上的差异有统计学意义(χ^(2)=8.576,P<0.05)。二元logistic回归分析结果显示在监测村(OR=2.093, 95%CI:1.489~2.941)、高年龄(OR=1.028, 95%CI:1.013~1.043)、曾诊断为SFTS(OR=3.089, 95%CI:1.021~9.346)、从事农业生产(OR=1.728, 95%CI:1.090~2.741)、曾被蜱虫叮咬过(OR=1.990, 95%CI:1.366~2.898)均是IgG抗体阳性的危险因素(均P<0.05)。结论 本研究发现安徽省高发地区自然人群中SFTS特异性IgG抗体阳性率较高,应加强对高发地区人群的健康干预,降低人群感染风险。Objective The purpose of this study was to understand the level of IgG in serum of natural people in areas with high incidence of severe fever with thrombocytopenia syndrome(SFTS)in Anhui Province and its influencing factors,so as to provide basis for the prevention and control of SFTS.Methods The serum samples and epidemiological data of natural population in areas with high incidence of SFTS were collected in the year of 2021 and divided into immunoglobulin G(IgG)negative group and positive group according to the results of IgG antibody test,and compare the demographic characteristics,past health status,environmental and medium exposure between the two groups.χ^(2) or Z test were used for univariate analysis,and logistic regression model was used for multivariate analysis.Results A total of 1255 cases were included in this study,of which 174 cases(13.86%)were IgG antibody positive.The univariate analysis showed that there was a significant difference in the demographic characteristics of the two groups in terms of village type and age(all P<0.05).There was a significant difference in the past health status of the two groups in terms of whether SFTS was diagnosed or not(χ^(2)=13.678,P<0.05).There was a significant difference in the environmental exposure of the two groups in terms of engaging in agricultural production,being bitten by ticks,living with weed and ticks around residential areas,and working in the field(P<0.05).There was a significant difference in the medium exposure of the two groups in terms of sitting and lying near the rat hole(χ^(2)=8.576,P<0.05).The binary logistic regression analysis showed that the monitoring villages(OR=2.093,95%CI:1.489-2.941),high age(OR=1.028,95%CI:1.013-1.043),had been diagnosed with SFTS(OR=3.089,95%CI:1.021-9.346),engaged in agricultural production(OR=1.728,95%CI:1.090-2.741),and had been bitten by ticks(OR=1.990,95%CI:1.366-2.898)were the risk factors for IgG antibody positive(all P<0.05).Conclusions This study finds that the IgG antibody positive rate is higher

关 键 词：发热伴血小板减少综合征 抗体 新发传染病 

分 类 号：R181.8[医药卫生—流行病学]