RORγt调节肠道免疫功能的研究进展  

Research progress of RORγt in intestinal immunomodulation

作　　者：王艺璇 宋旗 刘森 WANG Yixuan;SONG Qi;LIU Sen(Collaborative Innovation Center of Industrial Fermentation(Ministry of Education&Hubei Province),Hubei University of Technology,Wuhan,430068;Key Laboratory of Fermentation Engineering(Ministry of Education),Hubei University of Technology,Wuhan 430068;Hubei WEL-SAFE Biotechnology Co.,Ltd.,Ezhou 436006,China)

机构地区：[1]湖北工业大学工业发酵省部共建协同创新中心,湖北武汉430068 [2]湖北工业大学发酵工程教育部重点实验室,湖北武汉430068 [3]湖北微生元生物科技有限公司,湖北武汉436006

出　　处：《生物技术》2025年第1期127-134,共8页Biotechnology

基　　金：国家自然科学基金项目(31971150);湖北省杰出青年基金项目(2019CFA069);工业发酵省部共建协同创新中心开放基金。

摘　　要：肠黏膜内的免疫细胞大量表达RORγt,这些细胞与肠道微生物群之间的相互作用对于多方面肠道健康至关重要,包括诱导免疫细胞分化、预防病原微生物的侵袭、维护肠道黏膜的屏障功能。作为一种核激素受体,RORγt在诱导T细胞和淋巴细胞的发育方面发挥着关键作用,能够引发肠道黏膜的免疫耐受性和炎症反应。然而,RORγt在肠道内免疫调节中的确切作用机制尚不完全清楚。该文综述了关于RORγt参与肠道炎症的作用机制和调节肠道稳态相关的研究进展,旨在深入理解肠黏膜与肠道菌群的相互作用,为基于RORγt的免疫治疗策略提供参考。The immune cells in the intestinal mucosa were found to express RORγt(retinoid-related orphan receptor gamma t)abundantly,and their interaction with the intestinal microbiota was deemed crucial for various aspects of intestinal health,including the induction of immune cell differentiation,prevention of pathogenic microbial invasion,and maintenance of intestinal mucosal barrier function.As a nuclear hormone receptor,RORγt played a key role in inducing the development of T cells and lymphocytes,triggering immune tolerance and inflammatory responses in the intestinal mucosa.However,the exact mechanisms of RORγt in immune regulation within the intestine remained unclear.This paper reviewed the research progress on the mechanisms of RORγt involvement in intestinal inflammation and regulation of intestinal homeostasis,aiming to deepen the understanding of the interaction between the intestinal mucosa and the gut microbiota and provide references for immune therapy strategies based on RORγt.

关 键 词：RORΓT 肠黏膜 免疫细胞 肠道微生物 肠道炎症 细胞分化 肠道稳态 

分 类 号：R392[医药卫生—免疫学]