妊娠期糖尿病患者体质量指数与单核细胞/高密度脂蛋白胆固醇比值及中性粒细胞/淋巴细胞比值的相关性分析  

Analysis on the correlations between body mass index and monocyte/high density lipoprotein cholesterol ratio,neutrophil/lymphocyte ratio in gestational diabetes mellitus patients

作　　者：王茜 张东铭[1] 张丹阳 武嘉毅 WANG Xi;ZHANG Dong-ming;ZHANG Dan-yang;WU Jia-yi(Department of Endocrinology,the Second Affiliated Hospital of Zhengzhou University,Zhengzhou,He'nan 450000,China)

机构地区：[1]郑州大学第二附属医院内分泌科,河南郑州450000

出　　处：《中国妇幼保健》2025年第5期777-781,共5页Maternal and Child Health Care of China

基　　金：河南省科技发展计划项目(232102310152)。

摘　　要：目的 探讨妊娠期糖尿病(GDM)患者体质量指数(BMI)与单核细胞/高密度脂蛋白胆固醇比值(MHR)及中性粒细胞/淋巴细胞比值(NLR)的相关性。方法 选取2021年9月—2023年6月于郑州大学第二附属医院就诊的GDM患者272例,按BMI分为正常体质量组(70例)、超重组(95例)、肥胖组(107例)。分析BMI与MHR及NLR的相关性。结果 正常体质量组、超重组、肥胖组孕周、BMI、孕前BMI、体质量、体脂率(PBF)、内脏脂肪指数(VAI)、空腹血糖(FPG)、糖化血红蛋白(HbA1c)、三酰甘油(TG)、MHR、NLR、中性粒细胞(N)、单核细胞(M)、淋巴细胞(L)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、血小板计数(PLT)、总胆固醇(TC)、丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、血小板/淋巴细胞比值(PLR)、三酰甘油-葡萄糖指数(TyG)比较差异均有统计学意义(均P<0.05)。Spearman相关性分析显示:MHR、NLR与BMI、PBF、VAI、N、M、PLT、FPG、HbA1c、TG、PLR、TyG、孕周、孕前BMI、体质量均呈正相关(均P<0.05),与L、HDL-C均呈负相关(均P<0.05)。多元线性回归分析结果显示:BMI、N、M、L、HDL-C、NLR是MHR的影响因素,BMI、N、L、M、PLT、TG、HDL-C、PLR、MHR是NLR的影响因素(均P<0.05)。logistic回归分析结果显示:超重、肥胖是MHR、NLR升高的危险因素(MHR:OR=1.844,3.449;NLR:OR=1.822,3.394)。结论 GDM患者的MHR、NLR与BMI呈正相关,超重和肥胖是MHR、NLR升高的危险因素。Objective To explore the correlations between body mass index(BMI)and monocyte/high-density lipoprotein cholesterol ratio(MHR),neutrophil/lymphocyte ratio(NLR)in gestational diabetes mellitus(GDM)patients.Methods A total of 272 GDM patients treated in the Second Affiliated Hospital of Zhengzhou University from September 2021 to June 2023 were selected and divided into normal weight group(70 cases),overweight group(95 cases),and obese group(107 cases)according to BMI.The correlations between BMI and MHR,NLR were analyzed.Results There were statistically significant differences in gestational week,BMI,BMI before pregnancy,body weight,body fat rate(PBF),visceral fat index(VAI),fasting blood-glucose(FPG),glycosylated hemoglobin(HbA1c),triacylglycerol(TG),MHR,NLR,neutrophil granulocyte(N),monocyte(M),lymphocyte(L),high-density lipoprotein cholesterol(HDL-C),lowdensity lipoprotein cholesterol(LDL-C),platelet(PLT),total cholesterol(TC),alanine aminotransferase(ALT),aspartic transaminase(AST),platelet/lymphocyte ratio(PLR),triacylglycerol-glucose index(TyG)among normal weight group,overweight group,and obese group(all P<0.05).Spearman correlation analysis showed that MHR and NLR were positively correlated with BMI,PBF,VAI,N,M,PLT,FPG,HbA1c,TG,PLR,TyG,gestational week,BMI before pregnancy,and body weight(all P<0.05),MHR and NLR were negatively correlated with L and HDL-C(all P<0.05).Multivariate linear regression analysis showed that BMI,N,M,L,HDL-C,and NLR were influencing factors for MHR,while BMI,N,L,M,PLT,TG,HDL-C,PLR,and MHR were influencing factors for NLR(all P<0.05).logistic regression analysis showed that overweight and obesity were risk factors for increased MHR and NLR(MHR:OR=1.844,3.449;NLR:OR=1.822,3.394).Conclusion There is positive correlation between MHR,NLR and BMI in GDM patients.Overweight and obesity are independent risk factors for increased MHR and NLR.

关 键 词：妊娠期糖尿病 体质量指数 单核细胞/高密度脂蛋白胆固醇比值 中性粒细胞/淋巴细胞比值 

分 类 号：R714.256[医药卫生—妇产科学]