人细小病毒B19抗体在不良妊娠中的筛查价值  

Application value of human parvovirus B19 in abnormal pregnancy

作　　者：李翠[1] 段忠亮[1] 应春妹[1] LI Cui;DUAN Zhong-liang;YING Chun-mei(Obstetrics and Gynecology Hospital of Fudan University,Shanghai,200011,China)

机构地区：[1]复旦大学附属妇产科医院,上海200011

出　　处：《中国妇幼保健》2025年第5期806-809,共4页Maternal and Child Health Care of China

摘　　要：目的 探讨上海复旦大学附属妇产医院孕前检查、孕后人细小病毒B19的抗体阳性情况及与胎儿生长受限、复发性自然流产的相关性。方法 回顾性分析2020年1月—2021年5月,在复旦大学附属妇产科医院进行孕前检查的育龄女性及早孕后细小病毒B19抗体(IgM和IgG)情况;以孕前检查女性为对照,比较分析B19V抗体阳性率在复发性自然流产、胎儿生长受限患者的差异。结果 共有2 915例人员信息纳入本次回顾分析,根据怀孕情况,分为1 599例孕前检查女性,其中90例(5.63%)显示B19V抗体阳性;孕后检测该项目者1 316例,阳性143例为10.87%。整体来说随着年龄的增长,B19V抗体阳性率增高。IgM型抗体相对较少,IgG型抗体相对较多。根据不同妊娠结局分组,复发性自然流产患者阳性率为12.84%(38/257),显著高于对照组(P<0.001);胎儿生长受限患者阳性率为12.90%(12/93),显著高于对照组(P<0.01)。结论 人细小病毒B19抗体阳性率与复发性自然流产及胎儿生长受限的发生有相关性,应加强育龄期女性细小病毒B19的筛查。Objective To investigate the prevalence of human parvovirus B19 infection(IgM and IgG)before and after pregnancy in Obstetrics and Gynecology Hospital of Fudan University and its correlation with fetal growth restriction and recurrent spontaneous abortion.Methods The prevalence of human parvovirus B19 infection in women of childbearing age and after early pregnancy in the Obstetrics and Gynecology Hospital of Fudan University from January 2020 to May 2021 was analyzed retrospectively,and the positive rate of human parvovirus B19 in patients with recurrent spontaneous abortion and fetal growth restriction was compared and analyzed.Results A total of 2915 patients were included in this retrospective analysis,including 1599 women who were examined before pregnancy,of which 90(5.63%)were positive for human parvovirus B19 antibody.1316 cases were tested after pregnancy,and the positive rate was 10.87%.On the whole,the positive rate of human parvovirus B19 antibody increased with the increase of age.The IgM type antibody was relatively less than the IgG type antibody.According to different pregnancy outcomes,the positive rate of patients with recurrent spontaneous abortion was 12.84%(33/257),which was significantly higher than that of the control group women who were examined before pregnancy(P<0.001);the positive rate of patients with fetal growth restriction was 12.90%(12/93),which was also significantly higher than that in the control group(P<0.01).Conclusion Human parvovirus B19 infection is related to recurrent spontaneous abortion and fetal growth restriction.The screening of human parvovirus B19 in women of childbearing age should be strengthened.

关 键 词：人细小病毒B19 胎儿生长受限 复发性自然流产 

分 类 号：R714.2[医药卫生—妇产科学]