基于数据挖掘分析新安医学治疗肺结节的用药规律  

Analysis of Xin'an Medicine's Medication Rules for the Treatment of Pulmonary Nodules based on Data Mining

作　　者：江瑜 彭静 张涵雨 叶青 孙敏 赵心怡 唐杰 胡玉龙 江国庆 JIANG Yu;PENG Jing;ZHANG Hangyu;YE Qin;SUN min;ZHAO Xinyi;TANG Jie;HU Yulong;JIANG Guoqing(Huangshan Xin’an Traditional Medicine Research Institute,Anhui Huangshan 245000,China)

机构地区：[1]黄山市新安医学研究中心,安徽黄山245000

出　　处：《中医药临床杂志》2025年第3期484-489,共6页Clinical Journal of Traditional Chinese Medicine

基　　金：安徽省红十字会中医药传承创新发展研究项目:基于新安医学文献的肺结节方剂研究(2022ZYZD04);安徽省中医药传承创新科研项目:基于新安医学文献的肺结节方剂研究(2022CCZC25)。

摘　　要：目的:基于数据挖掘分析现代新安医学治疗肺结节的用药规律,以期为相关临床研究拓展思路和提供参考价值。方法:从黄山市中医医院的新安医学结节专科门诊收集2022年1月至2023年7月的肺结节患者就诊资料,利用数据挖掘技术对处方中的药物进行频数统计、聚类分析、关联规则分析及关联网络统计分析。结果:纳入的269首处方中共涉及203味中药,出现频数位于前5位的药物分别为浙贝母、甘草、瓜蒌、桔梗、皂角刺,药性主要以寒、温为主;药味以苦、甘、辛为主;归经则以归肺、脾、肝经为主;按功效分类,排在前3位的依次为化痰止咳平喘药、补虚药和清热药;聚类分析结果显示高频中药主要聚为5类;通过关联规则分析,得出药物组合中置信度为100%的药对有7个;根据药物关联网络分析结果,得出治疗肺结节的核心处方为瓜蒌、甘草、浙贝母、桔梗、皂角刺、三七、藕节、猫爪草、枳壳、仙鹤草。结论:新安医家治疗肺结节从肺、肝、脾三脏入手,以“先行开郁,进以缓补建功,再祛痰散结,标本兼治”为主要治则,其核心处方组方规律明晰、独具特色,对肺结节的中医治疗及临床应用具有一定的指导意义。Objective:To analyze the medication rules of modern Xin’an medicine for the treatment of pulmonary nodules based on data mining,in order to expand ideas and provide reference value for related clinical research.Meth-ods:The medical records of patients with pulmonary nodules from January 2022 to July 2023 were collected from the Xin’an Medicine Nodule Specialist Clinic of Huangshan Hospital of Traditional Chinese Medicine,and data mining technology was used to perform frequency statistics,cluster analysis,association rule analysis and association network statistical analysis on the drugs in the prescriptions.Results:A total of 203 Chinese medicines were involved in the 269 prescriptions included.The top five drugs with the highest frequency were Fritillaria thunbergii,Licorice,Tricho-santhes,Platycodon grandiflorum,and Gleditsia sinensis.The properties of the drugs were mainly cold and warm;the tastes were mainly bitter,sweet,and pungent;the meridians they entered were mainly lung,spleen,and liver meridians;according to the efficacy classification,the top three were expectorant,cough-relieving,and asthma-relieving drugs,tonic drugs,and heat-clearing drugs;cluster analysis results showed that high-frequency Chinese medicines were mainly clustered into five categories;through association rule analysis,it was found that there were 7 drug pairs with a confidence of 100%in the drug combination;according to the results of drug association network analysis,the core prescriptions for the treatment of pulmonary nodules were Trichosanthes,Licorice,Fritillaria thunbergii,Platycodon grandiflorum,Gleditsia sinensis,Panax notoginseng,Lotus Root,Cat’s Claw,Citrus aurantium,and Agrimoniae.Con-clusion:Xin’an doctors treat pulmonary nodules by starting with the lungs,liver,and spleen,with the main principle of“first relieving depression,then slowly replenishing and strengthening the body,then removing phlegm and dispers-ing nodules,treating both the symptoms and the root causes”.The core prescription composition rules a

关 键 词：新安医学 肺结节 数据分析 处方用药规律 

分 类 号：R256.1[医药卫生—中医内科学]