基于数据挖掘分析吕勇治疗慢性肾衰竭用药规律  

Analysis of LV Yong's Medication Pattern in Treating Chronic Renal Failure based on Data Mining

作　　者：张茹 吕勇[2] ZHANG Ru;LYU Yong(Anhui University of Chinese Medicine,Anhui Hefei 230031,China;The First Affiliated Hospital of Anhui University of Chinese Medicine,Anhui Hefei 230031,China)

机构地区：[1]安徽中医药大学第一临床医学院,安徽合肥230031 [2]安徽中医药大学第一附属医院,安徽合肥230031

出　　处：《中医药临床杂志》2025年第3期494-500,共7页Clinical Journal of Traditional Chinese Medicine

基　　金：吕勇安徽省名中医工作室建设项目,项目编号:皖中医药发展秘[2023]23;全国名中医传承工作室建设项目(国中医药办人教函[2022]245号);安徽高校自然科学研究重点项目(KJ2021A0566);安徽中医药大学2023年大学生创新创业训练计划项目(S202310369036)。

摘　　要：目的:基于中医传承辅助平台(V2.5)软件,分析吕勇主任治疗慢性肾衰竭(chronic renal failure,CRF)的用药规律。方法:收集2021年7月—2023年7月就诊于安徽中医药大学第一附属医院,吕主任的CRF患者门诊病历,筛选出符合该研究的110份病案,有效处方169首,录入中医传承辅助平台(V2.5)软件,统计所用药物的频数、性味、归经和功效,并对高频数药物进行关联规则分析,分析吕主任治疗CRF的用药规律。结果:169首处方中,涉及中药150个,频数≥55次的药物共18个,前10位的中药依次为黄芪、大黄、肉苁蓉、土茯苓、甘草、白术、车前草、薏苡仁、骨碎补、茯苓。四气以温、平、寒为主,凉、热次之;五味以甘、苦、辛为主,咸、酸、涩次之;归经以肝、脾、肾、肺、胃经为主,心、大肠、胆等经次之。得到12个核心药物组合及6个新方组合。结论:吕主任治疗CRF从“脾肾亏虚为本,瘀毒浊为标”的病机出发,确立培本清源的基本治疗原则和攻补兼施,寓攻于补的诊疗思路以及补益脾肾、化瘀泄浊解毒的组方法则。Objective:To analyze the medication rules of Director LV Yong in the treatment of chronic renal failure(CRF)based on the TCM inheritance auxiliary platform(V2.5)software.Methods:The outpatient medical records of CRF patients of DirectoR LV who visited the First Affiliated Hospital of Anhui University of Traditional Chinese Medi-cine from July 2021 to July 2023 were collected,and 110 medical records and 169 valid prescriptions that met the re-quirements of this study were screened out and entered into the TCM inheritance auxiliary platform(V2.5)software.The frequency,nature,taste,meridians and efficacy of the drugs used were counted,and the association rules of the high-frequency drugs were analyzed to analyze the medication rules of Director LV in the treatment of CRF.Results:Among the 169 prescriptions,150 Chinese medicines were involved,and 18 medicines with a frequency of≥55 times were involved.The top 10 Chinese medicines were Astragalus,Rhubarb,Cistanche,Smilax,Licorice,Atractylodes,Plantago,Coix Seed,Drynaria,and Poria.The four Qi were mainly warm,neutral,and cold,followed by cool and hot;the five flavors were mainly sweet,bitter,and pungent,followed by salty,sour,and astringent;the meridians were mainly liver,spleen,kidney,lung,and stomach,followed by heart,large intestine,and gallbladder.12 core drug combinations and 6 new prescription combinations were obtained.Conclusion:Director Lu treated CRF based on the pathogenesis of“spleen and kidney deficiency as the root,blood stasis and turbidity as the symptom”,established the basic treatment principle of strengthening the root and clearing the source,and the diagnosis and treatment ideas of attacking and supplementing,and combining attack with supplementing,as well as the combination of methods of tonifying the spleen and kidney,re-moving blood stasis,purging turbidity,and detoxifying.

关 键 词：慢性肾衰竭 用药规律 数据挖掘 中医药传承 

分 类 号：R256.5[医药卫生—中医内科学]