COPD患者抑郁状态危险因素及其对免疫功能的影响  

Risk factors for depression in COPD patients and effects on immune function

作　　者：张锦梅 胡丹丹[2] 颜一琴 项丽涵 张安安 李亚蓉 ZHANG JInmei;HU Dandan;YAN Yiqin;XIANG LIhan;ZHANG Anan;LI Yarong(Zhejiang Chinese Medical University,Zhejiang Hangzhou 310000,China;The Third Affiliated Hospital of Zhejiang Chinese Medical University,Zhejiang Hangzhou 310005,China)

机构地区：[1]浙江中医药大学,浙江杭州310053 [2]浙江中医药大学附属第三医院,浙江杭州310005

出　　处：《中医药临床杂志》2025年第3期514-519,共6页Clinical Journal of Traditional Chinese Medicine

基　　金：浙江省中医药科技计划一般项目(2022ZB197,2021ZB163);浙江省中医药科技计划重点项目(2021ZZ018)。

摘　　要：目的:探讨慢性阻塞性肺病(Chronic Obstructive Pulmonary Disease,COPD)患者抑郁状态危险因素,以及抑郁状态对免疫功能的影响。方法:该研究对象为2022年5月1日—2024年4月31日于浙江中医药大学附属第三医院就诊的COPD稳定期患者143例,收集患者的一般资料与淋巴细胞亚群测定结果,使用汉密尔顿抑郁量表(Hamilton depression scale,HAMD-17)对患者进行评估,应用SPSS 27.0统计软件对结果进行数据分析。结果:检出COPD合并抑郁患者52例,检出率达36.4%,其中低BMI、有吸烟史、家庭人均年收入≤7万元、合并其他慢性疾病、中度及以上气流受限、1年内急性加重2次以上均是COPD患者合并抑郁的危险因素,COPD合并抑郁组患者外周血中CD3^(+)%、CD4^(+)%、CD4^(+)/CD8^(+)、CD19^(+)%显著低于非抑郁组,CD8^(+)%、CD16^(+)CD56^(+)%无统计学差异。结论:COPD患者合并抑郁较为普遍,且与患者免疫功能有关,临床上应给予足够的关注。Objective:Exploring risk factors for depressive states in patients with chronic obstructive pulmonary disease(COPD),and the effect of depressive states on immune function.Methods:The subjects of this study were 143 patients with stable COPD who attended the Third Affiliated Hospital of Zhejiang University of Traditional Chi-nese Medicine from 1 May 2022 to 31 April 2024.General information about the patients and the results of lympho-cyte subpopulation measurements were collected,and patients were assessed using the Hamilton Depression Scale-17(HAMD-17),then SPSS 27.0 statistical software was applied for data analysis of the results.Results:52 complicated with depression,with a diagnosis rate of 36.4%.Among them,low BMI,history of smoking,annual per capita house-hold income≤70,000 yuan,comorbidity with other chronic diseases,moderate or higher airflow limitation,and more than 2 acute exacerbations within 1 year may increase the risk of depression.CD3^(+)%,CD4^(+)%,CD4^(+)/CD8^(+),and CD19^(+)%in the peripheral blood of patients in the COPD combined with depression group were significantly lower than in the non-depressed group,and nosignificant difference between CD8^(+)%,CD16^(+)CD56^(+)%.Conclusion:Comorbid depression is more common in patients with COPD and is related to the patient’s immune function,which should be given adequate clinical attention.

关 键 词：COPD 抑郁症 淋巴细胞亚群 免疫功能 

分 类 号：R563[医药卫生—呼吸系统]