肝豆状核变性认知障碍中医证候特征研究  

Study on the Characteristics of Traditional Chinese Medicine Syndromes in Cognitive Disorder of Hepatolenticular Degeneration

作　　者：江鹏宇 许金波 吴丽敏[3] 籍志慧 张念 银苗朱 韩辉[1] JIANG Pengyu;XU Jinbo;WU Limin;JI Zhihui;ZHANG Nian;YIN Miaozhu;HAN Hui(The First Affiliated Hospital of Anhui University of Chinese Medicine,Anhui Hefei 230031,China;Anhui Hospital Affiliated to the Pediatric Hospital of Fudan University,Anhui Hefei 230051,China;The First Affiliated Hospital of University of Science and Technology of China,Anhui Hefei 230001,China)

机构地区：[1]安徽中医药大学第一附属医院,安徽合肥230031 [2]复旦大学附属儿科医院安徽医院,安徽合肥230051 [3]中国科学技术大学附属第一医院,安徽合肥230001

出　　处：《中医药临床杂志》2025年第3期526-531,共6页Clinical Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(82374212,81971446);安徽省科技厅临床转化项目(202204295107020044)。

摘　　要：目的:探究肝豆状核变性(HLD)认知障碍的中医证候分布特点,旨在为该病的中医药临床诊疗提供中医辨证支持与依据。方法:纳入安徽中医药大学第一附属医院脑病中心的HLD患者,参照相关诊断标准,将患者分为认知障碍组(CD组)218例和无认知障碍组(HLD组)305例。进行中医证候调查及证候评分并展开分析。结果:HLD组和CD组在性别、年龄、病程、文化程度方面无统计学差异(P>0.05)。CD组中包含4种中医证候要素在分布频率和证候积分上高于HLD组,即“痰湿”“血瘀”“肾阴虚”及“肾阳虚”(P<0.05);CD组“多证候”所占比例高于HLD组(P<0.01)。结论:肾虚、痰湿、血瘀可能是HLD认知障碍的关键中医证候要素,且该病多以证候复合形式呈现。Objective:To explore the distribution characteristics of traditional Chinese medicine(TCM)syndromes cognitive disorder associated with hepatolenticular degeneration(HLD),aiming to provide TCM syndrome differ-entiation support and basis for clinical diagnosis and treatment of this disease.Methods:Patients with HLD who were treated at the Encephalopathy Center of the First Affiliated Hospital of Anhui University of TCM were classified into the cognitive disorder group(CD group)with 218 cases and the non-cognitive disorder group(HLD group)with 305 cases,based on relevant diagnostic criteria.TCM syndrome investigation and syndrome scoring were performed and analyzed.Results:There were no statistically significant differences between the HLD group and the CD group in terms of gender,age,disease duration,and educational level(P>0.05).In the CD group,the distribution frequency and syndrome scores of four TCM syndrome elements were higher than those in the HLD group,namely phlegm-dampness,blood stasis,kidney yin deficiency,and kidney yang deficiency(P<0.05);the proportion of multiple syndromes was higher in the CD group than in the HLD group(P<0.01).Conclusion:Kidney deficiency,phlegm-dampness,and blood stasis may be key TCM syndrome elements of cognitive disorder in HLD,and the disease often presents in a composite syndrome form.

关 键 词：肝豆状核变性 认知障碍 中医证候 

分 类 号：R742.4[医药卫生—神经病学与精神病学]