重骨颗粒方治疗肝肾亏虚型膝骨关节炎合并骨质疏松症的临床疗效观察  

Clinical Observation on the Efficacy of Chonggu Granule Recipe i n Treating Liver-kidney Deficiency Type KOA Combined with OP

作　　者：孙克勤 王雨晴 谌曦[2] 黄传兵[2] SUN Keqin;WANG Yuqing;SHEN Xi;HUANG Chuanbing(Anhui University of Chinese Medicine,Anhui Hefei 230012,China;The First Affiliated Hospital of Anhui University of Chinese Medicine,Anhui Hefei 230031,China)

机构地区：[1]安徽中医药大学第一临床医学院,安徽合肥230012 [2]安徽中医药大学第一附属医院,安徽合肥230031

出　　处：《中医药临床杂志》2025年第3期556-561,共6页Clinical Journal of Traditional Chinese Medicine

基　　金：大健康研究院新安医学与中医药现代化研究所专项资金(2023CXMMTCM004);安徽省名中医工作室建设项目(中发展[2022]5号);安徽省优势专科(皖中医药服务秘[2022]34号)。

摘　　要：目的:探讨重骨颗粒方对肝肾亏虚型膝骨关节炎(KOA)合并骨质疏松症(OP)的患者的疗效及生活质量。方法:2022年8月—2024年5月安徽省中医院风湿免疫科住院治疗的KOA合并OP患者40例,随机分为对照组和治疗组,每组20例。对照组予以阿法骨化醇软胶囊和盐酸氨基葡萄糖口服3个月,治疗组在对照组基础上内服重骨颗粒3个月。观察2组患者临床疗效改变,监测治疗前后炎症指标血沉(erythrocyte sedimentation rate,ESR)、超敏C反应蛋白(hypersensitive C-reactive protein,hs-CRP)、白介素-6的变化,治疗前后股骨颈、Ward’s三角区骨密度水平改变,治疗前后中医证候积分、视觉模拟量表(VAS)评分、西安大略和麦克马斯特大学骨关节炎指数(WOMAC)量表评分、Lysholm评分、生活质量量表积分变化。结果:治疗组的临床疗效优于对照组,治疗后治疗组的炎症指标ESR、hs-CRP水平降低程度均显著大于对照组,治疗后治疗组股骨颈、Ward’s三角区骨密度水平升高程度均显著高于对照组,治疗后治疗组中医证候积分、VAS评分、WOMAC评分、Lysholm评分、生活质量量表积分改善程度均显著优于对照组,差异均有统计学意义。结论:对于肝肾亏虚型KOA合并OP的患者,在服用常规抗骨质疏松西药基础上,予以重骨颗粒方治疗,能够表现良好的临床疗效,并且能够明显改善肝肾亏虚型KOA合并OP患者的髋部骨密度水平,中医证候表现、生活质量、膝关节疼痛症状和关节功能均有较优良的恢复。Objective:To explore the efficacy and quality of life of Chonggu Granules for patients with liver-kidney deficiency type KOA combined with OP;Methods:A total of 40 patients with KOA combined with OP who were hospi-talized in the Department of Rheumatology and Immunology of Anhui Provincial Hospital of Traditional Chinese Medi-cine from August 2022 to May 2024 were selected and randomly divided into a control group and a treatment group,with 20 cases in each group.The control group was given alfacalcidol soft capsules and glucosamine hydrochloride orally for 3 months,and the treatment group was given Chonggu Granules for 3 months on the basis of the control group.The clinical efficacy of the two groups of patients was observed,and the changes of inflammatory indicators such as erythrocyte sedimentation rate(ESR),hypersensitive C-reactive protein(hs-CRP),and interleukin-6(IL-6)before and after treatment were monitored.The changes of bone mineral density(BMD)levels of femoral neck and Ward’s triangle before and after treatment,TCM syndrome scores,visual analogue scale(VAS)scores,Western Ontario and McMas-ter Universities Osteoarthritis Index(WOMAC)scores,Lysholm scores,and quality of life scale(SF-36)scores before and after treatment were also monitored.Results:The clinical efficacy of the treatment group was better than that of the control group.After treatment,the levels of inflammatory indicators ESR and hs-CRP in the treatment group were significantly lower than those in the control group.After treatment,the levels of bone mineral density in the femoral neck and Ward’s triangle in the treatment group were significantly higher than those in the control group.After treat-ment,the improvement of TCM syndrome score,VAS score,WOMAC score,Lysholm score and quality of life scale score in the treatment group were significantly better than those in the control group.The differences were statistically significant.Conclusion:For patients with liver-kidney deficiency type KOA combined with OP,the Chonggu granule prescri

关 键 词：重骨颗粒 膝骨关节炎 骨质疏松症 肝肾亏虚 

分 类 号：R681[医药卫生—骨科学]