参芪固本破壁饮片结合督灸治疗肝癌癌因性疲乏临床研究  

Clinical Study on Shenqi Guben Pobi Decoction(参芪固本破壁饮)Combined with Moxibustion at Du Meridian Treating Fatigue Caused by Liver Cancer

作　　者：莫小艾[1] 蒋开平[1] 谢悠青 任健[1] 黄凯舟 MO Xiaoai;JIANG Kaiping;XIE Youqing;REN Jian;HUANG Kaizhou(Foshan Hospital of Traditional Chinese Medicine,Foshan 528000,Guangdong,China)

机构地区：[1]佛山市中医院,广东佛山528000

出　　处：《中华中医药学刊》2025年第3期116-119,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：国家中医药管理局全国名老中医药专家传承工作室项目(国中医药人教发[2017]29号);广东省中医药局科研项目(20202187);佛山市医学类科技攻关项目(1920001000800)。

摘　　要：目的观察参芪固本破壁饮片结合督灸治疗肝癌癌因性疲乏临床效果。方法将医院收治的120例肝癌癌因性疲乏患者(2020年10月—2023年5月)以随机数字表法分为中医组与常规组,各组60例患者,常规组患者采取睡眠管理、营养指导及运动疗法、心理疏导等常规治疗,中医组在常规治疗基础上给予患者参芪固本破壁饮片结合督灸治疗,治疗及研究过程中常规组脱落3例,中医组脱落5例,常规组剩余患者57例,中医组剩余患者55例,各组患者临床数据观察:临床疗效、治疗前后患者中医症候积分(神疲、气短乏力、自汗、懒言、失眠心悸、头晕眼花等)变化及Piper疲乏修正量表评分(Piper's Fatigue Scale,PFS)变化,并采取汉密尔顿焦虑量表-14(Hamilton Anxiety Scale-14,HAMA-14)与汉密尔顿抑郁量表-17(Hamilton Depression Scale-17,HAMD-17)评估各组患者负面情绪,采取匹兹堡睡眠指数(Pittsburgh Sleep Quality Index,PSQI)评估患者治疗前后睡眠质量情况,采取Spitzer生活质量指数(Spitzer Quality of Life Index,SQLI)评估各组患者治疗前后生活质量变化,采取医院自愿治疗满意度问卷调查各组患者满意率情况。结果中医组患者治疗总有效率(96.36%)比常规组患者(84.21%)更高,P<0.05;治疗前各组患者中医症候积分(神疲、气短乏力、自汗、懒言、失眠心悸、头晕眼花等)、PFS评分、HAMA-14评分、HAMD-17、PSQI评分以及SQLI评分比较,P>0.05,治疗后各组患者中医症候积分(神疲、气短乏力、自汗、懒言、失眠心悸、头晕眼花等)、PFS评分、HAMA-14评分、HAMD-17、PSQI评分以及SQLI评分均明显改善,而中医组患者治疗后中医症候积分(神疲、气短乏力、自汗、懒言、失眠心悸、头晕眼花等)、PFS评分、HAMA-14评分、HAMD-17、PSQI评分以及SQLI评分等指标均改善优于常规组患者,P<0.05;中医组患者治疗满意率(93.36%)比常规组患者治疗满意率(84.21%)更高,P<0.05。结�Objective To observe the clinical effect of Shenqi Guben Pobi Decoction(参芪固本破壁饮)combined with moxi-bustion at Du meridian on liver cancer fatigue.Methods A total of 120 patients with fatigue due to liver cancer admitted to the hospital from October 2020 to May 2023 were divided into traditional Chinese medicine(TCM)group and conventional group by means of random number table,with 60 patients in each group.The conventional group received routine treatment such as sleep management,nutritional guidance,exercise therapy and psychological counseling.On the basis of conventional treatment,the pa-tients in the TCM group were given Shenqi Guben Pobi Decoction combined with moxibustion at Du meridian treatment.In the course of treatment,3 cases fell off in the conventional group and 5 cases in the TCM group.There were 57 cases remained in the conventional group and 55 cases in the TCM group.The clinical data observation of patients in each group included the clinical efficacy,the changes of TCM symptom scores(fatigue,shortness of breath,spontaneous sweating,lazy speech,insomnia palpita-tion,dizziness,etc.)and Piper's Fatigue Scale(PFS)scores before and after treatment.Hamilton Anxiety Scale-14(HAMA-14)and Hamilton Depression Scale-17(HAMD-17)were used to assess the negative emotions of the patients in each group.The Pittsburgh sleep quality index(PSQI)was used to evaluate the sleep quality of the patients before and after treatment,and the Spitzer Quality of life index(SQLI)was used to evaluate the changes of patients'quality of life before and after treatment,and vol-untary treatment satisfaction questionnaire was adopted to investigate the satisfaction rate of patients in each group.Results The total effective rate of the TCM group(96.36%)was higher than that of the conventional group(84.21%)(P<0.05).Before treatment,TCM syndrome scores(fatigue,shortness of breath,spontaneous sweating,lazy speech,insomnia palpitation,dizziness,etc.),PFS score,HAMA-14 score,HAMD-17 score,PSQI score and SQLI score were not s

关 键 词：肝癌癌因性疲乏 督灸 参芪固本破壁饮片 临床疗效 中医症候积分 负面情绪 

分 类 号：R256.4[医药卫生—中医内科学]