超声介入射频消融术联合莲芪煎剂治疗原发性肝癌疗效观察  

Curative Effect of Interventional Radiofrequency Ultrasound Ablation Combined with Lianqi Decoction(莲芪煎剂)in Treatment of Primary Liver Cancer

作　　者：贺文娟 郭志勇 武磊 李瑛琪 HE Wenjuan;GUO Zhiyong;WU Lei;LI Yingqi(Yuncheng Central Hospital,Yuncheng 044000,Shanxi,China)

机构地区：[1]运城市中心医院,山西运城044000

出　　处：《中华中医药学刊》2025年第3期231-234,I0036,共5页Chinese Archives of Traditional Chinese Medicine

基　　金：山西省医学重点科研项目(2020XM59)。

摘　　要：目的探究超声介入射频消融术治疗联合莲芪煎剂对原发性肝癌患者的近期临床疗效、肿瘤标志物水平及免疫功能指标的影响。方法回顾性选取2018年6月—2020年6月医院收治的90例原发性肝癌患者,按照治疗方案不同分为常规组和观察组各55例,其中常规组采取射频消融术治疗,观察组在常规组的基础上联合使用莲芪煎剂治疗。观察对比两组患者的近期疗效情况、血清T淋巴细胞亚群表达水平、血清种球标志物表达水平、肝功能、肝脏硬度及安全性情况。结果观察组的近期临床总有效率显著高于常规组(P<0.05)。治疗后,观察组患者的甲胎蛋白(Alpha fetoprotein,AFP)、血清癌胚抗原(Carcinoembryonic antigen,CEA)、糖类抗原199(Carbohydrate antigen199,CA199)水平明显低于常规组患者(P<0.05)。治疗后,观察组患者的CD_(3)^(+)、CD_(4)^(+)高于常规组,CD_(8)^(+)低于常规组(P<0.05)。治疗后,观察组患者的ALT、AST、TBIL低于常规组(P<0.05)。观察组患者的总不良反应发生率显著低于常规组(P<0.05)。治疗后,观察组患者的LSM值优于常规组(P<0.05)。观察组患者两年内随访情况较常规组更佳(P<0.05)。结论超声介入射频消融术治疗联合莲芪煎剂对原发性肝癌患者的近期临床治疗效果更佳,能够显著改善患者的肿瘤标志物表达水平,改善肝脏弹性和肝功能情况,具有较好的临床应用前景。Objective To investigate the effect of ultrasound interventional radiofrequency ablation combined with Lianqi De-coction(莲芪煎剂)on the short-term clinical efficacy,tumor marker levels and immune function indexes of patients with prima-ry liver cancer.Methods A total of 90 patients with primary liver cancer who were treated in the hospital from June 2018 to June 2020 were retrospectively selected as the research subjects.According to the different treatment plans of the patients,they were divided into a routine group and an observation group with 55 cases in each group.The routine group was treated with radiofre-quency ablation,and the observation group was treated with Lianqi Decoction on the basis of the routine group.The short-term efficacy,expression levels of serum T lymphocyte subsets,expression levels of serum seed bulb markers,liver function,liver hard-ness and safety of the two groups were observed and compared.Results The short-term clinical total effective rate of the obser-vation group was significantly higher than that of the conventional group(P<0.05).After treatment,the levels of alpha fetopro-tein(AFP),carcinoembryonic antigen(CEA)and carbohydrate antigen 199(CA199)in the observation group were significantly lower than those in the conventional group(P<0.05).After treatment,the levels of CD_(3)^(+)and CD_(4)^(+)in the observation group were higher than those in the conventional group,and CD_(8)^(+)was lower than those in the conventional group(P<0.05).After treat-ment,the levels of alanine transaminase(ALT),aspartate transaminase(AST)and total bilirubin(TBIL)in the observation group were lower than those in the conventional group(P<0.05).The incidence of total adverse reactions in the observation group was significantly lower than that in the conventional group(P<0.05).After treatment,the liver stiffness measurernents(LSM)value of the observation group was better than that of the conventional group(P<0.05).The patients in the observation group were better than those in the conventional group

关 键 词：原发性肝癌 超声介入治疗 射频消融术 莲芪煎剂 肿瘤标志物 肝弹性 

分 类 号：R256.4[医药卫生—中医内科学]