胰岛素泵强化治疗联合个体化营养治疗在妊娠期糖尿病中的应用效果及对妊娠结局的影响  

Effects of Intensified Insulin Pump Therapy Combined with Individualized Nutritional Treatment on Pregnancy Outcomes in Gestational Diabetes Mellitus

作　　者：郑凤霞 王佳佳 赵琦[1] ZHENG Fengxia;WANG Jiajia;ZHAO Qi(Department of Obstetrics and Gynecology,Zhoukou Central Hospital,Zhoukou Henan 466000,China;Department of Endocrinology and Nutrition,Zhoukou Central Hospital,Zhoukou Henan 466000,China)

机构地区：[1]周口市中心医院妇产科,河南周口466000 [2]周口市中心医院内分泌营养膳食科,河南周口466000

出　　处：《临床研究》2025年第3期47-50,共4页Clinical Research

摘　　要：目的选取妊娠期糖尿病患者使用胰岛素泵强化治疗与个体化营养治疗结合分析其应用效果以及对妊娠结局的影响。方法选取周口市中心医院2020年3月至2023年3月收治的92例妊娠期糖尿病患者,随机分为对照组和研究组各46例,分析两组患者的相关临床指标。结果研究组患者治疗期间胰岛素剂量、血糖达标时间以及低血糖发生率均低于对照组,差异均有统计学意义(P<0.05)。治疗后,两组患者血糖水平下降,且研究组低于对照组,差异均有统计学意义(P<0.05);两组患者的糖化血红蛋白(HbA1c)均降低到正常水平,且研究组降到正常值的时间更短,差异有统计学意义(P<0.05)。治疗后,两组血清同型半胱氨酸(Hcy)及胱抑素C(Cys-C)水平均下降,且研究组低于对照组,差异均有统计学意义(P<0.05)。研究组不良妊娠结局发生率低于对照组,差异具有统计学意义(P<0.05)。研究组不良反应发生率低于对照组,差异无统计学意义(P>0.05)。结论对于妊娠期糖尿病患者进行胰岛素泵与个体化营养结合治疗,可以有效降低患者血糖水平,减少不良反应,安全可靠,值得临床应用。Objective To analyze the effects of combined intensified insulin pump therapy and individualized nutritional treatment on patients with gestational diabetes mellitus and its impact on pregnancy outcomes.Methods A total of 92 patients with Gestational diabetes mellitus admitted to Zhoukou Central Hospital from March 2020 to March 2023 were selected and randomly divided into a control group and a study group,with 46 cases in each group.Relevant clinical indicators of both groups were analyzed.Results During treatment,the insulin dosage,time to achieve blood glucose targets,and incidence of hypoglycemia in the study group were significantly lower than those in the control group(P<0.05).After treatment,blood glucose levels in both groups decreased,with the study group showing significantly lower levels compared to the control group(P<0.05).Both groups’glycated hemoglobin(HbA1c)levels decreased to normal ranges,with the study group reaching normal levels in a shorter time,demonstrating statistical significance(P<0.05).After treatment,serum homocysteine(Hcy)and cystatin C(Cys-C)levels decreased in both groups,with the study group having lower levels than the control group(P<0.05).The incidence of adverse pregnancy outcomes in the study group was lower than that in the control group,with statistical significance(P<0.05).The occurrence of adverse reactions in the study group was lower than in the control group,but the difference was not statistically significant(P>0.05).Conclusion Combined treatment with an insulin pump and individualized nutrition for patients with Gestational diabetes mellitus effectively reduces blood glucose levels and adverse reactions.This approach is safe and reliable,and its clinical application is warranted.

关 键 词：妊娠期糖尿病 胰岛素 个体化营养 妊娠结局 应用效果 

分 类 号：R540.4[医药卫生—心血管疾病]