低分子肝素钙对重症肺源性心脏病合并呼吸衰竭患者心肺功能的影响  

Effects of Low Molecular Weight Heparin Calcium on Cardiac and Pulmonary Functions in Patients with Severe Pulmonary Heart Disease Combined with Respiratory Failure

作　　者：胡江伟 HU Jiangwei(Department of Critical Care Medicine,People's Hospital of Xiuzhou District,Jiaxing,Zhejiang 314300,China)

机构地区：[1]嘉兴市秀洲区人民医院重症医学科,浙江嘉兴314300

出　　处：《临床研究》2025年第3期61-64,共4页Clinical Research

摘　　要：目的探析为重症肺源性心脏病合并呼吸衰竭患者,在对症治疗基础上,联合低分子肝素钙的临床效果。方法纳入2023年1月至2024年3月间嘉兴市秀洲区人民医院收治的80例重症肺源性心脏病合并呼吸衰竭症状患者,对其资料展开回顾性分析,采取对应治疗方案,40例实施对症治疗、无创呼吸机干预患者设对照组,40例同时应用低分子肝素钙干预患者设观察组。比较组间临床病情改善效果、血气指标检测、肺功能指标检测、心功能指标检测差异。结果观察组干预后重症肺源性心脏病合并呼吸衰竭疗效评价高于对照组,差异有统计学意义(P<0.05)。干预后观察组患者pH值、血氧饱和度、二氧化碳分压、动脉氧分压血气指标,优于对照组检测数据,差异有统计学意义(P<0.05)。干预后观察组患者第1秒用力呼气容积、用力肺活量、第1秒用力呼气容积/用力肺活量指标检测,优于对照组检测数据,差异有统计学意义(P<0.05)。针对心功能指标,观察组患者在干预后,左心室舒张末期内径,左心室收缩末期内径、左室射血分数优于对照组检测数据,差异有统计学意义(P<0.05)。结论低分子肝素钙可作为对重症肺源性心脏病合并呼吸衰竭患者辅助药物干预手段,可缓解症状恶化发展,改善患者血气指标和心肺功能。Objective To explore the clinical effects of combined low molecular weight heparin calcium in patients with severe pulmonary heart disease combined with respiratory failure,based on symptomatic treatment.Methods A total of 80 patients with severe pulmonary heart disease combined with respiratory failure admitted to the People's Hospital of Xiuzhou District,Jiaxing from January 2023 to March 2024 were included in this study.A retrospective analysis of patient data was conducted,and corresponding treatment strategies were implemented.Forty patients receiving symptomatic treatment and non-invasive ventilation were designated as the control group,while 40 patients receiving concurrent low molecular weight heparin calcium were designated as the observation group.Clinical improvement effects,blood gas indicators,pulmonary function indicators,and cardiac function indicators were compared between the two groups.Results The efficacy evaluation in the observation group after intervention was significantly higher than that in the control group(P<0.05).The blood gas indicators,including pH,oxygen saturation,carbon dioxide partial pressure,and arterial oxygen pressure,were superior in the observation group compared to the control group after intervention(P<0.05).The first second forced expiratory volume,forced vital capacity,and the ratio of first second forced expiratory volume to forced vital capacity were also significantly better in the observation group(P<0.05).For cardiac function indicators,the left ventricle end-diastolic diameter,left ventricle end-systolic diameter,and left ventricular ejection fraction were all superior in the observation group after intervention(P<0.05).Conclusion Low molecular weight heparin calcium can be used as an adjunctive therapeutic intervention for patients with severe pulmonary heart disease combined with respiratory failure.This treatment can alleviate symptom deterioration and improve blood gas indicators and cardiopulmonary function,ultimately supporting the recovery of patients.

关 键 词：低分子肝素钙 无创呼吸机 重症肺源性心脏病 呼吸衰竭 心肺功能 

分 类 号：R563.8[医药卫生—呼吸系统]