睡眠平衡术结合常规疗法对顽固性失眠的疗效及神经递质的影响  

Effects of Sleep Balance Surgery Combined with Conventional Therapy on Ref ractory Insomni a and I t s Impact on Neurotransmitters

作　　者：司慧敏 陈亚杰 张星 乔慧敏 SI Huimin;CHEN Yajie;ZHANG Xing;QIAO Huimin(Department of Anesthesiology and Perioperative Medicine,Xinzheng Public People's Hospital,Xinzheng Henan 451100,China)

机构地区：[1]新郑市公立人民医院麻醉与围手术医学科,河南新郑451100

出　　处：《临床研究》2025年第3期89-93,共5页Clinical Research

摘　　要：目的探讨睡眠平衡术结合常规疗法对顽固性失眠的疗效及神经递质的影响。方法选取2021年1月至2023年5月新郑市公立人民医院收治的86例顽固性失眠患者为研究对象,依靠随机数字表法将其进一步分为对照组(43例)与观察组(43例),对照组行常规治疗,观察组则在此基础上增加睡眠平衡术治疗。比较两组患者不良反应发生率、临床疗效以及治疗前后睡眠情况、睡眠质量、神经递质相关指标变化情况。结果治疗期间,86例顽固性失眠患者中共有3例剔除(观察组剔除1例,对照组剔除2例),最终观察组42例,对照组41例有效病例纳入结果分析。治疗前,两组睡眠情况比较,差异无统计学意义(P>0.05);治疗后,两组患者觉醒次数、睡眠潜伏期均低于治疗前,总睡眠时间、睡眠期均高于治疗前,且观察组觉醒次数、睡眠潜伏时间均低于对照组,总睡眠时间、睡眠期均高于对照组,差异有统计学意义(P<0.05)。治疗前,两组睡眠质量比较,差异无统计学意义(P>0.05);治疗后,两组入睡时间、睡眠时间、日间功能障碍、睡眠障碍、睡眠效率、催眠药物、睡眠质量评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗前,两组神经递质相关指标比较,差异无统计学意义(P>0.05);治疗后,两组5-羟色胺(5-HT)、5-羟吲哚乙酸(5-HIAA)、多巴胺(DA)、去甲肾上腺素(NE)水平均高于治疗前,且观察组上述指标均高于对照组,差异有统计学意义(P<0.05)。观察组治疗有效率(92.86%)高于对照组(75.61%),差异有统计学意义(P<0.05)。观察组患者出现恶心3例,头晕2例,瞌睡1例;对照组患者出现恶心1例,头晕1例,头晕伴瞌睡1例,胃肠道不适1例。观察组不良反应发生率(14.29%)与对照组(9.76%)比较,差异无统计学意义(χ^(2)校正=0.088,P=0.767)。结论睡眠平衡术结合常规疗法治疗顽固性失眠疗效显著,可以改善患者睡眠情况,提升�Objective To explore the efficacy of sleep balance surgery combined with conventional therapy on refractory insomnia and its effects on neurotransmitters.Methods A total of 86 patients with refractory insomnia treated at Xinzheng Public People's Hospital from January 2021 to May 2023 were selected for this study.Patients were further divided into a control group(n=43)and an observation group(n=43)using a random number table method.The control group received conventional treatment,while the observation group received sleep balance surgery in addition to conventional treatment.The incidence of adverse reactions,clinical efficacy,changes in sleep conditions,sleep quality,and relevant neurotransmitter indicators before and after treatment were compared between the two groups.Results During the treatment period,3 patients were excluded(1 from the observation group and 2 from the control group),resulting in 42 valid cases in the observation group and 41 in the control group for the final analysis.Before treatment,there were no statistically significant differences in sleep conditions between the two groups(P>0.05).After treatment,both groups had fewer nocturnal awakenings and shorter sleep latency times compared to before treatment,with total sleep time and sleep duration increased.The observation group showed significantly lower awakening times and sleep latency,and higher total sleep time and sleep duration than the control group(P<0.05).There was no significant difference in sleep quality between the two groups before treatment(P>0.05);however,after treatment,the observation group had better scores in sleep onset time,sleep duration,daytime dysfunction,sleep disturbances,sleep efficiency,hypnotic medication usage,and overall sleep quality compared to the control group(P<0.05).Before treatment,there were no significant differences in neurotransmitter indicators between the groups(P>0.05);post-treatment,the levels of serotonin(5-HT),5-hydroxyindoleacetic acid(5-HIAA),dopamine(DA),and norepinephrine(NE)increased in bot

关 键 词：顽固性失眠 睡眠平衡术 神经递质 睡眠质量 临床疗效 

分 类 号：R473.74[医药卫生—护理学]