喘咳1号方穴位敷贴联合特布他林联合多索茶碱治疗慢性阻塞性肺病急性加重期的研究  

Study on the Effects of Acupoint application of Chuanke No.1 formula with Terbutaline and Doxofylline in Treating Acute Exacerbation of Chronic Obstructive Pulmonary Disease

作　　者：胡克崇 贾蒙蒙 王爱丹 孙鹏雷 林日武 HU Kechong;JIA Mengmeng;WANG Aidan;SUN Penglei;LIN Riwu(Department of Internal Medicine,Rui'an Traditional Chinese Medicine Hospital,Rui'an,Zhejiang 325200,China)

机构地区：[1]瑞安市中医院内科一病区,浙江瑞安325200

出　　处：《临床研究》2025年第3期121-125,共5页Clinical Research

摘　　要：目的分析慢性阻塞性肺疾病急性加重期患者在接受特布他林、多索茶碱治疗时,联合应用喘咳1号方穴位敷贴治疗的疗效。方法选取2023年1月至2024年1月瑞安市中医院收治的70例慢性阻塞性肺疾病急性加重期患者;经随机单盲原则将全部患者分成对照组与研究组各35例,对照组接受特布他林、多索茶碱治疗,研究组则在特布他林与多索茶碱治疗的基础上联合应用喘咳1号方穴位敷贴治疗。比较两组的临床疗效、肺通气功能、血常规、C反应蛋白(CRP)、血气分析指标以及中医症候积分及不良反应发生情况。结果研究组治疗有效率(97.14%)高于对照组(74.29%),差异有统计学意义(P<0.05)。治疗后,两组第1秒用力呼气容积(FEV_1)、用力肺活量(FVC)以及用力呼气1秒率(FEV_1/FVC)水平明显增加,且研究组FEV_1、FVC及FEV_1/FVC水平均高于对照组,差异有统计学意义(P<0.05)。治疗后,两组中性粒细胞百分数(N)及白细胞计数(WBC)及C反应蛋白(CRP)水平均明显降低,且研究组N、WBC及CRP水平均低于对照组,差异有统计学意义(P<0.05)。治疗后,两组动脉血氧分压(PaO_(2))、pH水平均明显增加,动脉血二氧化碳分压(PaCO_(2))水平均明显降低,且研究组PaO_(2)、pH水平均高于对照组,PaCO_(2)水平低于对照组,差异有统计学意义(P<0.05)。治疗后,两组中医证候积分均明显降低,且研究组中医证候积分低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论应用多索茶碱与特布他林治疗慢性阻塞性肺疾病急性加重期患者时,联合喘咳1号方穴位敷贴治疗能改善患者症状及实验室指标,有效减轻炎症反应,提升患者肺功能,改善血气分析指标,具有安全性。Objective To analyze the efficacy of combining acupoint application of Chuanke No.1 formula with terbutaline and doxofylline in patients with acute exacerbation of chronic obstructive pulmonary disease.Methods Seventy patients admitted with acute exacerbation of Chronic obstructive pulmonary disease to Rui'an Traditional Chinese Medicine Hospital from January 2023 to January 2024 were selected.Based on the principles of randomized single-blind allocation,patients were divided into a control group and a study group,with 35 patients in each group.The control group received treatment with terbutaline and doxofylline,while the study group received acupoint application of Chuanke No.1 formula in addition to terbutaline and doxofylline.The clinical efficacy,pulmonary function,blood routine,C-reactive protein(CRP),blood gas analysis indices,traditional Chinese medicine syndrome scores,and incidence of adverse reactions were compared between the two groups.Results The treatment effective rate in the study group(97.14%)was significantly higher than that of the control group(74.29%),with statistical significance(P<0.05).After treatment,the first-second forced expiratory volume(FEV1),forced vital capacity(FVC),and FEV1/FVC ratio increased significantly in both groups,with the study group showing higher levels than the control group(P<0.05).After treatment,the percentage of neutrophils(N),white blood cell count(WBC),and CRP levels decreased significantly in both groups,but the study group had lower levels of N,WBC,and CRP compared to the control group(P<0.05).Arterial oxygen partial pressure(PaO2)and pH levels increased significantly post-treatment,while arterial carbon dioxide partial pressure(PaCO2)decreased significantly,with the study group exhibiting higher PaO2 and pH levels and lower PaCO2 levels compared to the control group(P<0.05).Additionally,both groups displayed significant reductions in traditional Chinese medicine syndrome scores post-treatment,with the study group scoring lower than the control group(P<0.05).

关 键 词：慢性阻塞性肺疾病 急性加重期 特布他林 多索茶碱 喘咳1号方 穴位敷贴 

分 类 号：R563[医药卫生—呼吸系统]