四磨汤治疗消化道术后胃肠功能障碍的Meta分析  

Meta-Analysis on Simotang in Postoperative Gastrointestinal Dysfunction after Gastrointestinal Surgery

作　　者：管洁 罗倩 蔺晓源[2] 周赛男[2] GUAN Jie;LUO Qian;LIN Xiaoyuan;ZHOU Sainan(The First Traditional Chinese Medicine Clinical College of Hunan University of Chinese Medicine,Changsha 410007,China;The First Hospital of Hunan University of Chinese Medicine,Changsha 41000,China)

机构地区：[1]湖南中医药大学第一中医临床学院,湖南长沙410007 [2]湖南中医药大学第一附属医院,湖南长沙410007

出　　处：《湖北民族大学学报(医学版)》2025年第1期21-25,共5页Journal of Hubei Minzu University(Medical Edition)

基　　金：湖南省自然科学基金(2024JJ9435);湖南省中医药科研计划基金(B2024047);长沙市自然科学基金(kq2403098);中药粉体与创新药物省部共建国家重点实验室培育基地开放基金(23PTKF1010)。

摘　　要：目的系统评价四磨汤治疗消化道术后胃肠功能障碍的临床疗效。方法计算机检索中英文数据库:中国知网(CNKI)、维普中文期刊数据库(VIP)、万方学术期刊库(Wanfang)、中国生物医学文献数据库(CBM)及PubMed数据库,时间限定为建库至2023年12月。通过Note Express软件对检索后题录进行管理,按照预先设定的纳入及排除标准,独立筛选并交叉核对后,确定符合要求的四磨汤治疗消化道术后胃功能障碍的随机对照试验研究并提取数据,通过Cochrane协作网风险偏倚评估工具对文献质量进行评价,通过Revman 5.3软件对结局指标进行Meta分析并统计结果。结果共筛选符合条件文献22篇,涉及患者1624例。Meta分析结果显示,经四磨汤处理后患者术后首次排气、排便时间,肠鸣音恢复时间,腹胀发生率等均低于对照组(P<0.05)。结论四磨汤在治疗消化道术后胃肠功能障碍中有良好的疗效表现,但证据不够充分,仍需更多大样本、高质量的随机对照试验提供更为有利的循证依据。Objective To evaluate the clinical efficacy of Simotang in postoperative gastrointestinal dysfunction(POGD)after gastrointestinal surgery.Methods The randomized controlled trials(RCTs)were retrieved from CNKI,VIP,Wanfang,CBM,and PubMed from the database construction to December 2023.The post-retrieval study was managed by Note Express software,and after independent screening and cross-checking according to preset inclusion and exclusion criteria,RCTs of Simotang in POGD after gastrointestinal surgery that met the requirements were identified and data were extracted.The quality of the literature was evaluated by the Cochrane Collaboration Network Risk of Bias Assessment Tool,and Meta-analysis of the outcome indicators was performed by Revman 5.3 software and the results were counted.Results A total of 22 articles from the eligible literature were screened,involving 1624 patients.Meta-analysis results showed that the performance of outcome indicators such as time to first postoperative gas and defecation,time to recovery of bowel sounds,and incidence of abdominal distension in patients treated with Simotang was better than that of the control group.Conclusion Simotang has good efficacy in POGD after gastrointestinal surgery,but the evidence is insufficient,and there is still a need for more large-sample size and high-quality randomised controlled trials to provide a more favourable evidence-based basis.

关 键 词：四磨汤 术后胃肠功能障碍 消化道 META分析 

分 类 号：R285[医药卫生—中药学]