The Effects of Structural&Materials Design on the Mechanisms of Tissue Integration with the 3D Printed Polyether-Ether-Ketone Cranial Implants in Vivo  

作　　者：Ling Wang Ziyu Wang Jiayin Liu Yijun Hui Yanwen Su Chenrui Zhang Changning Sun Kaishu Li Dichen Li Yawei Liu 

机构地区：[1]State Key Laboratory for Manufacturing System Engineering,Xi’an Jiaotong University,Xi’an,710054,China [2]School of Mechanical Engineering,Xi’an Jiaotong University,Xi’an,710054,China [3]NMPA Key Laboratory for Research and Evaluation of Additive Manufacturing Medical Devices,Xi’an,710054,China [4]Department of Neurosurgery&Medical Research Center,Shunde Hospital,Southern Medical University(The First People’s Hospital of Shunde Foshan),Foshan,528300,China [5]Cell Therapy Center,Beijing Institute of Geriatrics,Xuanwu Hospital Capital Medical University,National Clinical Research Center for Geriatric Diseases,Key Laboratory of Neurodegenerative Diseases,Ministry of Education,Beijing,100053,China [6]Department of Neurosurgery,The Sixth Affiliated Hospital of Guangzhou Medical University,Qingyuan People’s Hospital,Qingyuan,511518,China

出　　处：《Additive Manufacturing Frontiers》2024年第1期173-182,共10页增材制造前沿(英文)

基　　金：supported by National Natural Science Foundation of China(Grant.Nos.51835010,12202347);Natural Science Basic Research Program of Shaanxi Province of China(Grant.No.2022JQ-378);Fundamental Research Funds for the Central Universities and the Program for Innovation Team of Shaanxi Province of China(Grant.No.2023-CX-TD-17);Natural Science Foundation of Guangdong Province of China(Grant.No.2022A1515012552).

摘　　要：3D printed polyether-ether-ketone(PEEK)implant has become a popular clinical alternative to implants made of titanium alloy for cranial bone substitutes due to its bone-match properties,however its biological inert hin-dered the progress of clinical applications of such material.To enhance the tissue integration capability of PEEK implants and promote their long-term stability,cranial implants of gradient porous structures were designed and manufactured via fused filament fabrication(FFF)3D printing technology in both PEEK and PEEK/HA com-posites materials,then functionally evaluation of the implants on the tissue in-growth and the osteointegration mechanisms was conducted via animal tests.The 3D printed PEEK scaffold was found to have 2-5 folds of the compressive strength to those of the natural cranial bone.The in vivo studies verified that the porous PEEK/HA scaffold could effectively induce the bone ingrowth to form a stable biointegration boundary surrounding the host bone tissue after 4 weeks of implantation.Moreover,the PEEK/HA scaffold showed no significant advantages in improving the soft tissue in-growth,only making its distribution more evenly.It is also interestingly to find out that the vertically connective pores throughout the implant did not enhance the tissue binding force even though it did promote the nutrient transportation.In conclusion,the use of PEEK/HA composite material and a well-designed porous structure was proved to be an effective approach to improve the biointegration between the implant and host tissues.

关 键 词：FFF 3D printing PEEK/HA composite Gradient porous scaffold Cranial implant Biointegration 

分 类 号：TQ3[化学工程]