护延Ⅰ号方治疗慢性肾脏病2~3期患者临床观察  

Efficacy observation of HuyanⅠformula on chronic kidney disease in stage 2~3

作　　者：赵滢 贺怡宁 顾丽娜 何伟明 ZHAO Ying;HE Yi-ning;GU Li-na(First Clinical Medical College of Nanjing University of Chinese Medicine,Nanjing 210029,China;不详)

机构地区：[1]南京中医药大学第一临床医学院,南京210029 [2]南京中医药大学附属医院江苏省中医院

出　　处：《山西中医》2025年第3期11-13,共3页Shanxi Journal of Traditional Chinese Medicine

基　　金：江苏省中医药科技发展计划项目(编号:ZD202209);江苏省中医肾病医学创新中心项目(编号:苏卫科教【2022】15号)。

摘　　要：目的:观察护延Ⅰ号方治疗慢性肾脏病2~3期患者的临床疗效。方法:选取符合纳入标准的60例慢性肾脏病2~3期患者,随机分为对两组各30例。对照组采用西医基础治疗,治疗组在对照组基础上加用护延Ⅰ号方,疗程3个月,观察两组治疗前后临床疗效、中医临床症状积分、血清肌酐(Scr)、估算的肾小球滤过率(eGFR)和胱抑素C(Cys-C)水平。结果:治疗组临床总有效率80.00%明显高于对照组的53.33%,差异有统计学意义(P﹤0.05);治疗后,治疗组eGFR水平明显高于对照组,中医临床证候总积分、Scr水平明显低于对照组,差异均有统计学意义(P﹤0.05);Cys-C水平变化无明显差异。结论:护延Ⅰ号方联合西药治疗慢性肾脏病2~3期患者能显著改善患者临床症状,延缓肾功能衰退。Objective:To observe the clinical efficacy of HuyanⅠformula on chronic kidney disease in stage 2~3.Methods:60 cases of eligible patients with chronic kidney disease in stage 2~3 were selected and randomly divided into two groups,30 cases in each group.The control group was treated with basic western medicine,while the treatment group was treated plus with HuyanⅠformula on the basis of control group.The course of treatment was 3 months for both groups.Clinical efficacy,clinical symptom score of TCM and levels of serum creatinine(Scr),estimated glomerular filtration rate(eGFR)and cystatin C(Cys-C)were observed in two groups before and after treatment.Results:The total clinical effective rate of treatment group was 80.00%,which was significantly higher than 53.33%of control group,and the difference was statistically significant(P﹤0.05).After treatment,eGFR level of treatment group was significantly higher than that of control group;total score of clinical TCM syndromes and Scr level of treatment group were significantly lower than those of control group,and the differences were statistically significant(P﹤0.05);there was no significant difference in change of Cys-C level.Conclusion:HuyanⅠformula and western medicine for treating chronic kidney disease in stage 2~3 can significantly improve the clinical symptoms of patients,and delay renal failure.

关 键 词：慢性肾脏病 肾功能衰退 护延Ⅰ号方 中医药疗法 

分 类 号：R692[医药卫生—泌尿科学]