益气健脾利水方对脾气虚弱、水湿内停型慢性心力衰竭患者血浆脑钠肽与心肌酶谱水平的影响  

Effects of Yiqi Jianpi Lishui Decoction on Plasma Brain Natriuretic Peptide and Myocardial Enzyme Profile in Patients with Spleen Qi Deficiency and Water-Damp Retention Type Chronic Heart Failure

作　　者：张茜 陈云 张海帆 赵灵灵 ZHANG Qian;CHEN Yun;ZHANG Haifan;ZHAO Lingling(Luohe Traditional Chinese Medicine Hospital,Luohe 462000,China)

机构地区：[1]漯河市中医院,河南漯河462000

出　　处：《中医药信息》2025年第3期74-78,共5页Information on Traditional Chinese Medicine

基　　金：河南省中医药科学研究专项课题(2022ZY2074)。

摘　　要：目的:观察益气健脾利水方对脾气虚弱、水湿内停型慢性心力衰竭(CHF)的治疗效果,并分析其对血浆脑钠肽(BNP)与心肌酶谱水平影响。方法:选取符合纳入标准的CHF患者106例,依据区组随机法随机分为对照组和研究组,每组各53例。对照组给予常规西药治疗,研究组在常规西药治疗的基础上给予益气健脾利水方治疗,比较两组临床疗效及治疗前后血浆BNP、心肌肌钙蛋白Ⅰ(cTnⅠ),心肌酶谱和心功能指标。结果:研究组总有效率90.57%(48/53),高于对照组67.92%(36/53)(P<0.05)。和治疗前比较,两组治疗后BNP、cTnⅠ、乳酸脱氢酶(LDH)、谷草转氨酶(AST)、肌酸激酶同工酶(CK-MB)、肌酸激酶(CK)、LVSED、LVDED和LVMI均降低(P<0.05),LVEF、E/A升高(P<0.05),且研究组BNP、cTnⅠ、乳酸脱氢酶(LDH)、谷草转氨酶(AST)、肌酸激酶同工酶(CK-MB)、肌酸激酶(CK)、LVSED、LVDED和LVMI低于对照组(P<0.05),LVEF、E/A高于对照组(P<0.05)。结论:益气健脾利水方可提高CHF的临床疗效,降低血浆BNP、cTnⅠ水平,保护心肌,改善心功能。Objective:To observe the therapeutic effect of Yiqi Jianpi Lishui Decoction on chronic heart failure(CHF)of spleen Qi deficiency and water-damp retention type,and analyze its effects on plasma brain natriuretic peptide(BNP)and myocardial enzyme profile.Methods:A total of 106 CHF patients meeting the inclusion criteria were selected and randomly divided into a control group and a research group,with 53 patients in each group using block randomization.The control group received conventional Western medicine treatment,while the research group received the same plus Yiqi Jianpi Lishui Decoction.The clinical efficacy,plasma BNP,cardiac troponin I(cTnI),myocardial enzyme profile,and cardiac function indicators were compared before and after treatment.Results:The total effective rate in the research group was 90.57%(48/53),which was significantly higher than the control group's 67.92%(36/53)(P<0.05).After treatment,compared with pre-treatment,BNP,cTnI,lactate dehydrogenase(LDH),aspartate transaminase(AST),creatine kinase-MB(CK-MB),creatine kinase(CK),LV end-systolic diameter(LVSED),LV end-diastolic diameter(LVDED),and LV mass index(LVMI)all decreased(P<0.05),while left ventricular ejection fraction(LVEF)and E/A ratio increased(P<0.05).Additionally,the levels of BNP,cTnI,LDH,AST,CKMB,CK,LVSED,LVDED,and LVMI in the research group were lower than those in the control group(P<0.05),while LVEF and E/A were higher in the research group(P<0.05).Conclusion:Yiqi Jianpi Lishui Decoction can improve the clinical efficacy of CHF,lower plasma BNP and cTnI levels,protect the myocardium,and improve cardiac function.

关 键 词：益气健脾利水方 慢性心力衰竭 脑钠肽 心肌酶谱 

分 类 号：R54[医药卫生—心血管疾病]