Cell-autonomous innate immunity by proteasome-derived defence peptides  

作　　者：Karin Goldberg 

机构地区：[1]不详

出　　处：《四川生理科学杂志》2025年第3期584-584,共1页

摘　　要：For decades,antigen presentation on major histocompatibility complex class I for T cell-mediated immunity has been considered the primary function of proteasome-derived peptides1,2.However,whether the products of proteasomal degradation play additional parts in mounting immune responses remains unknown.Antimicrobial peptides serve as a first line of defence against invading pathogens before the adaptive immune system responds.Although the protective function of antimicrobial peptides across numerous tissues is well established,the cellular mechanisms underlying their generation are not fully understood.Here we uncover a role for proteasomes in the constitutive and bacterial-induced generation of defence peptides that impede bacterial growth both in vitro and in vivo by disrupting bacterial membranes.In silico prediction of proteome-wide proteasomal cleavage identified hundreds of thousands of potential proteasome-derived defence peptides with cationic properties that may be generated en route to degradation to act as a first line of defence.

关 键 词：AUTONOMOUS CONSTITUTIVE MOUNT 

分 类 号：O62[理学—有机化学]