Hs-CRP、SAA、PCT与AECOPD患者病情程度及预后的相关性分析  

Correlation analysis of Hs-CRP,SAA,PCT and the severity and prognosis of AECOPD

作　　者：曾怡春 何成光 Zeng Yi-chun;He Cheng-guang(Emergency Department,Fuzhou Maternal and Child Health Hospital,Fuzhou 344000,Jiangxi,China)

机构地区：[1]抚州市妇幼保健院急诊科,江西抚州344000

出　　处：《四川生理科学杂志》2025年第3期664-666,共3页

摘　　要：目的:分析超敏C反应蛋白(Hypersensitive C-reactive protein,Hs-CRP)、血清淀粉样蛋白A(Serum amyloid A,SAA)、降钙素原(Procalcitonin,PCT)与急性加重期慢性阻塞性肺疾病(Acute exacerbation of chronic obstructive pulmonary disease,AECOPD)患者病情程度及预后的相关性。方法:回顾性收集我院于2022年5月至2023年10月收治的73例AECOPD患者临床诊治及随访信息,其中病情严重程度由轻到重分别有22例、26例及25例,分别设为轻度组、中度组、重度组,同时收集同期行Hs-CRP、SAA、PCT指标检测的体检健康者的基本资料作为健康组。分析Hs-CRP、SAA、PCT 3项指标与AECOPD患者病情程度相关性;跟踪随访预后情况,对比预后良好组、预后不良组Hs-CRP、SAA、PCT水平。结果:轻度组、中度组、重度组Hs-CRP、SAA、PCT水平均高于健康组,且随着疾病程度增加,Hs-CRP、SAA、PCT水平越高(P<0.05);经相关性分析,Hs-CRP、SAA、PCT水平与AECOPD患者病情程度呈正相关性(P<0.05),经统计,预后良好52例、预后不良21例,预后良好组Hs-CRP、SAA、PCT水平低于预后不良组(P<0.05)。结论:AECOPD患者Hs-CRP、SAA、PCT水平普遍较高,且与疾病严重程度呈正相关性,检测以上3项指标可辅助评估预后情况。Objective:To analyze the correlation of Hs-CRP,SAA,PCT and the severity and prognosis of AECOPD.Method:The information on clinical diagnosis,treatment and follow-up of 73 patients with AECOPD admitted to our hospital from May 2022 to October 2023 was collected retrospectively.Among patients enrolled,there were 22,26 and 25 patients in mild,moderate and severe condition,respectively.They were defined as mild group,moderate group and severe group.Meanwhile,healthy individuals who received detection of Hs-CRP,SAA and PCT levels were taken as the healthy group.The correlation between Hs-CRP,SAA,PCT and the severity of AECOPD was analyzed.The levels of Hs-CRP,SAA,and PCT in the good prognosis group and the poor prognosis group were compared.Result:The levels of Hs-CRP,SAA,and PCT in the mild group,the moderate group,and the severe group were higher than those in the healthy group.Moreover,the levels of Hs-CRP,SAA,and PCT increased with the exacerbation of the disease(P<0.05).The levels of Hs-CRP,SAA,and PCT were positively correlated with the severity ofAECOPD(P<0.05).There were 52 cases with good prognosis and 21 cases with poor prognosis.The levels of Hs-CRP,SAA,and PCT in the good prognosis group were lower than those in the poor prognosis group(P<0.05).Conclusion:The levels of Hs-CRP,SAA,and PCT in patients with AECOPD are generally high,and positively correlated with the severity of the disease.Testing these three indicators can assist in evaluating prognosis.

关 键 词：分析超敏C反应蛋白 血清淀粉样蛋白A 降钙素原 急性加重期慢性阻塞性肺疾病 相关性 

分 类 号：R56[医药卫生—呼吸系统]