益气健脾汤对脾气亏虚型2型糖尿病患者胰高血糖素样肽-1和胰高血糖素的影响  

Effect of decoction for replenishing Qi and fortifying spleen on glucagon-like peptide-1 and glucagon in patients with type 2 diabetes mellitus with syndrome of spleen Qi deficiency

作　　者：张靖寅 李爱平 乔文琪 王仕清 于泽宇 田源[2] ZHANG Jingyin;LI Aiping;QIAO Wenqi;WANG Shiqing;YU Zeyu;TIAN Yuan(Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,Heilongjiang,China;The Third Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine,Harbin 150030,Heilongjiang,China)

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040 [2]黑龙江中医药大学附属第三医院,黑龙江哈尔滨150030

出　　处：《现代中西医结合杂志》2025年第3期325-330,共6页Modern Journal of Integrated Traditional Chinese and Western Medicine

基　　金：2017年教育厅优秀创新人才项目(UNPYSCT-2017227);黑龙江中医药管理局科研项目(ZHY2022-199);2021年度黑龙江省经济社会重点研究课题(基地专项)(21418)。

摘　　要：目的观察益气健脾汤对脾气亏虚型2型糖尿病(T2DM)患者胰高血糖素样肽-1(GLP-1)、胰高血糖素(GCG)的影响,探讨益气健脾汤的可能作用机制。方法纳入2023年12月—2024年3月就诊于黑龙江中医药大学附属第三医院内分泌(老年病)科的脾气亏虚型T2DM患者60例,按照随机数字表法平均分为治疗组和对照组,最终治疗组28例、对照组30例完成研究。对照组予以饮食、运动等糖尿病基础生活方式干预和盐酸二甲双胍片口服,治疗组在对照组治疗基础上给予益气健脾汤化裁口服,2组治疗周期均为6周。观察比较2组治疗前后中医证候积分、血糖指标[空腹血糖(FPG),口服葡萄糖耐量实验后30 min、60 min、120 min、180 min血糖,糖化血红蛋白(HbA1c)]及血清GLP-1、GCG水平。结果治疗后,2组中医证候积分均明显低于治疗前(P均<0.05),且治疗组明显低于对照组(P<0.05)。治疗后,治疗组FPG、HbA1c及血清GCG水平均明显低于治疗前及对照组(P均<0.05),血清GLP-1水平明显高于治疗前及对照组(P均<0.05),对照组血清GLP-1、GCG水平与治疗前比较差异均无统计学意义(P均>0.05)。结论益气健脾汤可能通过提高GLP-1水平、降低GCG水平来改善糖代谢,从而达到降糖的目的。Objective It is to observe the effect of decoction for replenishing Qi and fortifying spleen on glucagon-like peptide-1(GLP1)and glucagon(GCG)in patients with type 2 diabetes mellitus(T2DM)with syndrome of spleen Qi deficiency,so as to explore the mechanism of this medicine.Methods A total of 58 patients with T2DM with syndrome of spleen Qi deficiency treated in the Endocrinology(Geriatrics)Department of the Third Affiliated Hospital of Heilongjiang University of Chinese Medicine from December 2023 to March 2024 were selected,and were divided into treatment group and control group according to the random number table method.28 cases in the treatment group and 30 cases in the control group finally completed the study.The control group was given diet,exercise and other basic lifestyle interventions for diabetes and metformin hydrochloride tablets orally,and the treatment group was given modified decoction for replenishing Qi and fortifying spleen orally on the basis of treatment of the control group,both groups were treated for 6 weeks.The scores of traditional Chinese medical syndromes,blood glucose indexes[fasting plasma glucose(FPG),blood glucose at 30 min,60 min,120 min and 180 min after oral glucose tolerance test,glycated hemoglobin(HbA1c)]and serum levels of GLP-1 and GCG before and after treatment in the two groups were observed and compared.Results After treatment,the scores of traditional Chinese medical syndromes of both groups were significantly lower than those before treatment(both P<0.05),and the scores of the treatment group were significantly lower than those of the control group(all P<0.05).After treatment,the levels of FPG,HbA1c and serum GCG in the treatment group were significantly lower,while the serum level of GLP-1 was significantly higher than those before treatment and in the control groups(all P<0.05),there were no signifiant differences in the levels of serum GLP-1 and GCG between before and after treatment in the control group(all P>0.05).Conclusion Decoction for replenishing Qi and for

关 键 词：2型糖尿病 脾气亏虚证 益气健脾汤 胰高血糖素样肽-1 

分 类 号：R587.1[医药卫生—内分泌]