膳食抗氧化指数与老年肥胖症患者认知功能下降的关系  

Relationship between dietary antioxidant index and cognitive decline in elderly patients with obesity

作　　者：王丹[1] 王苹 张娜娜 Wang Dan;Wang Ping;Zhang Nana(Peking University First Hospital Taiyuan Hospital,Taiyuan 030009)

机构地区：[1]北京大学第一医院太原医院,太原030009

出　　处：《国际老年医学杂志》2025年第2期190-195,共6页International Journal of Geriatrics

基　　金：山西省卫生健康委科研课题(2022084)。

摘　　要：目的探讨膳食抗氧化指数(DAI)与老年肥胖症患者认知功能下降的关系。方法选取2021年6月-2023年12月北京大学第一医院太原医院收治的老年肥胖症患者200例。采集患者临床资料,简易精神状态检查量表(MMSE)评分评估患者认知功能,采用食物摄入频率问卷对食物摄入量进行评估,并计算DAI评分,将MMSE评分<27分患者纳入认知功能下降组,其余患者纳入认知功能正常组。比较两组临床资料、膳食摄入情况、DAI评分,logistic回归分析认知功能下降与DAI的相关性。结果200例老年肥胖症患者中MMSE<27分患者有39例,占比19.50%;两组年龄、糖尿病比例、体质量指数、甘油三酯、MMSE评分及各个维度评分比较,差异均有统计学意义(P<0.05);认知功能下降组总能量摄入量、饱和脂肪酸均高于认知功能正常组(P<0.05),蛋白质、维生素E、维生素B1、叶酸、总膳食纤维摄入量、DAI评分均低于认知功能正常组(P<0.05);logistic分析显示DAI与认知功能下降呈负相关(OR=0.861,95%CI:0.851~0.923,P=0.032)。在调整了年龄、糖尿病、BMI、TG、文化程度混杂因素(OR=0.902,95%CI:0.817~0.937,P=0.014)和额外调整了总能量摄入量(OR=0.913,95%CI:0.773~0.981,P=0.021)后,这种关联仍然显著。结论老年肥胖症患者中DAI与认知功能下降呈负相关,DAI评分越高,认知功能下降的风险越低。Objective To investigate the relationship between dietary antioxidant index(DAI)and cognitive function decline in elderly obese patients.Methods A total of 200 elderly obese patients admitted to Peking University First Hospital Taiyuan Hospital from June 2021 to December 2023 were selected.Clinical data of the patients were collected,the cognitive function of the patients was evaluated by MMSE score,food intake was evaluated by FFQ questionnaire,and DAI score was calculated.Patients with MMSE score<27 were included in the cognitive function decline group.The remaining patients were included in the group with normal cognitive function.Clinical data,dietary intake,DAI score and logistic regression were compared between the two groups to analyze the correlation between cognitive decline and DAI.Results Among 200 elderly obese patients,39 had MMSE<27,accounting for 19.50%.There were significant differences in age,proportion of diabetes mellitus,body mass index,triglyceride,MMSE score and scores of each dimension between the two groups(P<0.05).The total energy intake and saturated fatty acid of cognitive function decline group were higher than those of cognitive function normal group(P<0.05),the protein,vitamin E,vitamin B1,folate,total dietary fiber intake and DAI score of cognitive function decline group were lower than those of cognitive function normal group(P<0.05);logistic analysis showed that DAI was negatively correlated with cognitive function decline(OR=0.861,95%CI:0.851-0.923,P=0.032).After adjusting for confounding factors such as age,diabetes,BMI,TG and education(OR=0.902,95%CI:0.817-0.937,P=0.014)and total energy intake(OR=0.913,95%CI:0.773~0.981,P=0.021),the association remained significant.Conclusion Dietary antioxidant index is negatively correlated with cognitive decline in elderly obese patients,and the higher the DAI score,the lower the risk of cognitive decline.

关 键 词：肥胖症 膳食抗氧化指数 认知功能 

分 类 号：R65[医药卫生—外科学]