肠道微生态在老年2型糖尿病患者常见微血管病变中的研究进展  

Intestinal microecology and its impact on microvascular complications in elderly type 2 diabetes mellitus patients

作　　者：陈景连 李雪萌 刘军 Chen Jinglian;Li Xuemeng;Liu Jun(Laboratory of Pathogen Biology,Guangdong Medical University,Zhanjiang 524023;Zhanjiang Key Laboratory of Human Microecology and Clinical Translation Research,Zhanjiang 524023)

机构地区：[1]广东医科大学病原生物学实验室,湛江524023 [2]湛江市人体微生态研究与临床转化重点实验室,湛江524023

出　　处：《国际老年医学杂志》2025年第2期212-215,共4页International Journal of Geriatrics

基　　金：国家自然科学基金(82301752)。

摘　　要：2型糖尿病(T2DM)患者由于小动脉、毛细血管和小静脉等微循环血管在长期高糖环境下异常生长和通透性增高出现微血管病变,是导致老年T2DM患者失明、终末期肾衰竭、糖尿病性心肌病和周围神经病变的主要原因,对老年T2DM患者的生存及生活质量造成巨大威胁。肠道微生态组成和功能的改变可以直接影响年龄相关疾病,本文对肠道微生态在T2DM微血管病变中的研究现状作一综述,从新的角度寻找预防和治疗靶点,为T2DM微血管病变的防治提供新思路。Type 2 diabetes mellitus(T2DM)microvascular disease encompasses pathological alterations in the growth and permeability of microcirculatory vessels,including arterioles,capillaries and venules,driven by prolonged hyperglycemic conditions.Microangiopathy represents a primary contributor to blindness,end-stage renal failure,diabetic cardiomyopathy and peripheral neuropathy in elderly T2DM patients,posing significant risks to their survival and quality of life.In recent years,the intestinal microecology has emerged as a burgeoning area of research,with numerous studies highlighting its pivotal role in influencing age-related diseases.This review synthesizes current knowledge on the interplay between intestinal microecology in T2DM microangiopathy,exploring potential prevention and treatment targets from an innovative perspective,and offering novel insights for the management of T2DM-related microvascular complications.

关 键 词：2型糖尿病 微血管并发症 肠道微生态 

分 类 号：R58[医药卫生—内分泌]