基于化学成分、药理作用及网络药理学的蒙药珍珠质量标志物预测分析  

Predictive Analysis of Quality Markers of Zhenzhu(Margarita)in Mongolian Medicine Based on Chemical Composition,Pharmacological Effect and Network Pharmacology

作　　者：彭斯格热希 陈英松 特格喜白音 春兰 色林格 BORZIGIN Pengsigerexi;CHEN Yingsong;WANG Tegexibaiyin;CHUN Lan;SE Lin’ge(Inner Mongolia Minzu University,Mongolian Medicine College,Tongliao 028000,China;Affiliated Hospital of Inner Mongolia Minzu University,Tongliao 028000,China;Mongolian Medicine College,Inner Mongolia Medical University,Hohhot 010110,China;Medical College,Inner Mongolia Minzu University,Tongliao 028000,China)

机构地区：[1]内蒙古民族大学蒙医药学院,内蒙古通辽028000 [2]内蒙古民族大学附属医院,内蒙古通辽028000 [3]内蒙古医科大学蒙医药学院,内蒙古呼和浩特010110 [4]内蒙古民族大学医学院,内蒙古通辽028000

出　　处：《山东中医药大学学报》2025年第2期256-264,共9页Journal of Shandong University of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(编号:21868024);蒙药研发国家地方联合工程研究中心开放基金项目(编号:MDK2023039);内蒙古自治区研究生科研创新项目(编号:KC2024054B)。

摘　　要：蒙药珍珠作为传统蒙药材,具有抑制中枢神经、美白护肤、促进伤口愈合、增强免疫力、抗氧化、抗炎、保护心脏、抗衰老等多种药理作用。本文结合网络药理学分析预测出卟啉、柯蒲醇、亮氨酸、谷氨酸、异亮氨酸、苯丙氨酸、赖氨酸等化合物,借鉴中药质量标志物“成分有效性”概念,探寻与珍珠药理作用的一致性,将以上化合物确立为珍珠的质量标志物,并为今后珍珠质量标准研究提供新的思路和方法。参考文献54篇。As a traditional Mongolian medicinal,Zhenzhu(Margarita)has many pharmacological effects such as inhibiting the central nervous system,whitening and skin care,promoting wound healing,enhancing immunity,anti-oxidation,anti-inflammation,protecting the heart,anti-aging and so on.In this paper,porphyrin,copaol,leucine,glutamic acid,isoleucine,phenylalanine,lysine and other compounds were predicted by network pharmacological analysis.Referring to the concept of“component effectiveness”of quality markers of Chinese medicine,the consistency of their phar-macological effects with Zhenzhu was explored,and the above compounds were established as the quality markers of Zhenzhu.This paper also pro-vides new ideas and methods for the study of quality standards of Zhenzhu in the future.There are 54 references in total.

关 键 词：珍珠 蒙药 化学成分 药理作用 网络药理学 质量标志物 

分 类 号：R284.1[医药卫生—中药学]