慢性心力衰竭患者血清层黏蛋白水平与心力衰竭严重程度的相关性研究  

Correlation between serum laminin level and severity of heart failure in patients with chronic heart failure

作　　者：魏冯宁[1] 尹生磊 郝丹凤 沈美佳 李刚[1] WEI Feng-ning;YIN Sheng-lei;HAO Dan-feng(Department of Emergency,China-Japan Friendship Hospital,Beijing 100029,China)

机构地区：[1]中日友好医院急诊科,北京100029 [2]金寨县人民医院急诊科,安徽六安237399 [3]莱州荣军医院神经科,山东烟台261499 [4]陕西省人民医院急诊外科,陕西西安710068

出　　处：《中日友好医院学报》2025年第1期3-6,17,共5页Journal of China-Japan Friendship Hospital

摘　　要：目的:探讨慢性心力衰竭(CHF)患者血清层黏蛋白水平与心力衰竭严重程度的相关性。方法:选择2022年1月—2023年12月我院收治的160例CHF患者作为研究对象,另选取100例健康体检者作为对照组。比较不同心功能分级患者的血清层黏蛋白水平、N末端脑钠肽前体(NT-ProBNP)和左心室射血分数(LVEF)。采用Spearman秩相关分析CHF患者血清层黏蛋白与NT-ProBNP和LVEF指标的相关性。采用受试者工作特征曲线(ROC)曲线评价层黏蛋白对CHF患者Ⅲ级和Ⅳ级的预测价值。结果:CHF患者的NT-ProBNP水平显著高于对照组(P<0.05),LVEF水平显著低于对照组(P<0.05)。CHF患者随心功能分级的增加,层黏蛋白水平和NTProBNP水平显著升高、LVEF水平显著降低(P<0.05)。层黏蛋白与NT-ProBNP显著正相关(r=0.535,P=0.007),而与LVEF显著负相关(r=-0.449,P=0.001)。层黏蛋白预测CHF患者心功能Ⅲ级和Ⅳ级的AUC显著高于LVEF和NT-ProBNP预测的AUC。结论:血清层黏蛋白在CHF患者血清中呈现高表达,且与患者心功能分级正相关,在预测CHF心功能不同分级方面具有潜在的应用价值。Objective:To investigate the correlation between the level of serum laminin and the severity of heart failure in patients with chronic heart failure(CHF).Methods:A total of 160 patients with CHF admitted to our hospital from January 2022 to December 2023 were selected as the study objects,and 100healthy subjects as the control group.The levels of serum laminin,N-terminalpro-brain natriuretic peptide(NTProBNP)and left ventricular ejection fraction(LVEF)in patients with different stages of cardiac function were compared.Spearman rank correlation was used to analyze the correlation between serum laminin and NT-ProBNP and LVEF in CHF patients.ROC curve was used to evaluate the predictive value of laminin in the level Ⅲ and Ⅳ of CHF patients.Results:The level of NT-ProBNP in CHF patients was significantly higher than that in control group(P<0.05),and the level of LVEF in CHF patients was significantly lower than that in control group(P<0.05).The levels of laminin and NT-ProBNP were significantly increased and the level of LVEF was significantly decreased in CHF patients with the increase of spontaneous functional classification(P<0.05).There was a significant positive correlation between serum laminin level and NT-ProBNP(r=0.535,P=0.007),and a significant negative correlation between serum laminin level and LVEF(r=-0.449,P=0.001).The AUC predicted by laminin at the level Ⅲ and Ⅳ of cardiac function in CHF patients was significantly higher than that predicted by LVEF and NT-ProBNP.Conclusion:Serum laminin is highly expressed in the serum of CHF patients,and is closely related to NT-ProBNP and LVEF,which has potential application value in predicting the progression of cardiac function in CHF.

关 键 词：慢性心力衰竭 层黏蛋白 N末端脑钠肽前体 左室射血分数 

分 类 号：R541.6[医药卫生—心血管疾病]