Remission of iron overload in adipose tissue of obese mice by fatty acid-modified polyoxovanadates  

作　　者：Kun Chen Yu-Rong Qin Sheng-Qiu Liu Rou-Ling Chen 

机构地区：[1]South China Advanced Institute for Soft Matter Science and Technology,School of Emergent Soft Matter,South China University of Technology,Guangzhou,510641,China [2]Guangdong Provincial Key Laboratory of Technique and Equipment for Macromolecular Advanced Manufacturing,South China University of Technology,Guangzhou,510641,China [3]Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices,South China University of Technology,Guangzhou,510641,China [4]Department of Computer Science,City University of Hong Kong,Hong Kong,999077,China

出　　处：《Rare Metals》2025年第1期461-471,共11页稀有金属(英文版)

基　　金：supported by the National Natural Science Foundation of China(No.22101086);Guangzhou Basic and Applied Basic Research Project(No.202201010052);Guangdong Basic and Applied Basic Research Foundation(No.2023A1515140030).

摘　　要：Iron overload has been evidenced to contribute to obesity-associated metabolic disorders,including insulin resistance.Strategies to reduce iron levels might help manage the metabolic complications associated with obesity.Here,it is demonstrated that the specific accumulation of oleic acid-modified polyoxovanadates(OPOVs)in adipose tissue leads to the reduction of iron concentrations in adipocytes in mice fed with a high-fat diet(HFD).Conjugation of oleic acids to polyoxovanadates enables tissue-specific depletion of iron from white adipose tissue(WAT)by OPOVs,protecting mice from HFD-induced obesity and obesity-associated metabolic deteriorations.Glucose tolerance and insulin sensitivity are improved in OPOV-treated mice,which demonstrates that the OPOV-induced iron depletion can reverse the metabolic degeneration caused by HFD-induced obesity.Furthermore,a decrease in expression of the marker genes of iron overload suggests the participation of OPOVs in maintaining iron homeostasis and a potential medical application of vanadium clusters in targeting the iron overload caused by obesity.These findings underscore the potential of vanadate-based clusters tailored to address the complex interplay between iron metabolism and metabolic health.

关 键 词：POLYOXOVANADATES Lipophilic conjugation Obesity Iron overload Insulin resistance 

分 类 号：R58[医药卫生—内分泌]