Ce-doped defective titanium oxide coating with antibacterial,antioxidant and anti-inflammatory properties for potential application of peri-implantitis treatment  

作　　者：Yun-Hao Chen Shi-Wei Guan Min Xing Kelvin Wai-Kwok Yeung Xuan-Yong Liu Wen-Hao Qian Jing-Bo Yin Jia-Jun Qiu 

机构地区：[1]School of Materials Science and Engineering,Shanghai University,Shanghai,200444,China [2]State Key Laboratory of High Performance Ceramics and Superfine Microstructure,Shanghai Institute of Ceramics,Chinese Academy of Sciences,Shanghai,200050,China [3]Shanghai Xuhui District Dental Center,Shanghai,200032,China [4]Department of Orthopaedics and Traumatology,Li Ka Shing Faculty of Medicine,The University of Hong Kong,Hong Kong,999077,China [5]School of Chemistry and Materials Science,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Hangzhou,310024,China

出　　处：《Rare Metals》2025年第1期472-488,共17页稀有金属(英文版)

基　　金：supported by the National Natural Science Foundation of China(No.52272283);the Science and Technology Commission of Shanghai Municipality(Nos.22S31902900 and 22ZR1457600);Youth Innovation Promotion Association CAS(No.2023263);Young Elite Scientists Sponsorship Program by CAST(No.2022-2024QNRC001);General Research Fund of the Research Grants Council(No.17207719);the Health and Medical Research Fund(No.20190244).

摘　　要：Implant-related infections and tissue inflammation are the main factors for peri-implantitis.Lack of antibacterial activity and poor soft tissue sealing property increase the occurrence probability of peri-implantitis.To prevent and treat peri-implantitis,cerium-doped defective titanium oxide coatings are prepared on medical titanium surfaces by plasma electrolytic oxidation and thermal reduction treatment.In the darkness,Ce-doped defective titanium oxide coatings with micro-porous structure surface can inhibit the bacteria adhesion to some extent with antibacterial rates of 38.0%against S.aureus and 65.0%against E.coli.Under near infrared(NIR)irradiation,Ce-doped defective titanium oxide coatings show good photothermal antibacterial activity with antibacterial rates of 99.9%against S.aureus and 99.9%against E.coli.Moreover,with the increasing content of Ce-doping,the coatings exhibit higher capacity to scavenge hydrogen peroxide(H2O2)and 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid)radical cation(ABTS·+).The coatings with enhanced antioxidant effect can protect human gingival fibroblasts from oxidative stress damage by eliminating reactive oxygen species and promoting initial cell adhesion.Besides,Ce-doped coatings can regulate the immune microenvironment by up-regulating the expression of anti-inflammatory genes and down-regulating the pro-inflammatory genes.In vivo animal experiments further confirm the good antibacterial activity of Ce-doped defective titanium oxide coatings under NIR irradiation and good biosafety.This work provides a novel surface modification strategy for implant abutment,which shows good application prospects for preventing and treating peri-implantitis.

关 键 词：Peri-implantitis Antibacterial Soft tissue sealing Titanium oxide Cerium(Ce) 

分 类 号：TG1[金属学及工艺—金属学]