RADICAL:a rationally designed ion channel activated by ligand for chemogenetics  

作　　者：Heng Zhang Zhiwei Zheng Xiaoying Chen Lizhen Xu Chen Guo Jiawei Wang Yihui Cui Fan Yang 

机构地区：[1]Liangzhu Laboratory,Zhejiang University Medical Center,Hangzhou 311121,China [2]Kidney Disease Center of the First Affiliated Hospital and Department of Biophysics,Zhejiang University School of Medicine,Hangzhou 311121,China [3]Department of Neurobiology,Department of Neurology of Sir Run Run Shaw Hospital,Zhejiang University School of Medicine,Hangzhou 310058,China [4]NHC and CAMS Key Laboratory of Medical Neurobiology,MOE Frontier Science Center for Brain Research and Brain–Machine Integration,School of Brain Science and Brain Medicine,Zhejiang University,Hangzhou 310058,China

出　　处：《Protein & Cell》2025年第2期136-142,共7页蛋白质与细胞(英文版)

基　　金：supported by funding from the National Natural Science Foundation of China(32122040 and 31971040 to F.Y.;32071017 and 31922031 to Y.C.);Zhejiang Provincial Natural Science Foundation of China(LR20C050002 to F.Y.);China Postdoctoral Program for Innovative Talents(BX20230323 to H.Z.);China Postdoctoral Science Foundation(2024M752858 to H.Z.);The Fundamental Research Funds for the Central Universities(226-2022-00227 to F.Y.;226-2022-00149 to Y.C.);Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions(NYKFKT2019001 to Y.C.);The Fundamental Research Funds for the Central Universities(226-2022-00227 to F.Y.)。

摘　　要：Dear Editor,Manipulating neuronal activities by exogenous means is always much desired in the field of neuroscience and beyond.Though many optogenetics and chemogenetics tools,such as channelrhodopsins and DREADDs(Armbruster et al.,2007;Sternson and Roth,2014),have been developed and widely used,there are several limitations in these tools.For optogenetics,the invasiveness of implanted optical fiber is unavoidable.

关 键 词：RATIONAL CHANNEL LIMITATIONS 

分 类 号：Q421[生物学—神经生物学]