Retrospective:Advances and Opportunities of 3D Bioprinting in China over Three Decades  

作　　者：Xianhao Zhou Yongcong Fang Ting Zhang Zhuo Xiong 

机构地区：[1]Biomanufacturing Center,Department of Mechanical Engineering,Tsinghua University,Beijing,100084,China [2]Biomanufacturing and Rapid Forming Technology Key Laboratory of Beijing,Beijing,100084,China [3]"Biomanufacturing and Engineering Living Systems"Innovation International Talents Base(111 Base),Beijing,100084,China

出　　处：《Additive Manufacturing Frontiers》2024年第4期29-43,共15页增材制造前沿(英文)

基　　金：supported by National Natural Science Foundation of China(Grant Nos.U21A20394,52305314);Tsinghua-Toyota Joint Research Fund(Grant No.20223930093);National Key Research and Development Program of China(Grant No.2018YFA0703004).

摘　　要：Three-dimensional(3D)bioprinting,which has been applied in tissue engineering and regenerative medicine,uses biomaterials,cells,and other essential components to manufacture organs and tissues with specific biological functions and complex structures.Over the past 30 years,researchers have developed new 3D bioprinting technologies with improved manufacturing capabilities and expanded applications.Chinese research teams contributed significantly to this process.In this paper,we first reviewed the development history and major milestones in 3D bioprinting,categorizing them into two main strategies:"biomaterial-based indirect assembly"and"living cell-based direct assembly".This review further delved into the technical principles,recent advancements,advantages,disadvantages,and applications of each type of bioprinting technology.Finally,the challenges and future directions of 3D bioprinting were summarized to guide future research in China and foster advancements in this dynamic field.

关 键 词：3D bioprinting BIOFABRICATION Bioink Regenerative medicine Disease modeling 

分 类 号：F42[经济管理—产业经济]