疏风解毒胶囊联合沙丁胺醇气雾剂治疗慢性阻塞性肺病加重期的效果分析  

Analysis of the Effect of Shufeng Jiedu Capsules Combined with Salbutamol Aerosol in the Treatment of Severe Chronic Obstructive Pulmonary Disease

作　　者：巩彩凤 徐海玲 张克香 杨琼花 刘晨 GONG Cai-feng;XU Hai-ling;ZHANG Ke-xiang;YANG Qiong-hua;LIU Chen(Department of Respiratory and Critical Care Medicine,Wuwei People's Hospital,Wuwei,Gansu,733000,China)

机构地区：[1]武威市人民医院呼吸与危重症医学科,甘肃武威733000

出　　处：《现代生物医学进展》2025年第4期648-655,780,共9页Progress in Modern Biomedicine

基　　金：中国研究型医院学会科研项目(Y2023FH-WZYX04-05);武威市市级科技计划项目(WW23B02SF013)。

摘　　要：目的:分析疏风解毒胶囊联合沙丁胺醇气雾剂治疗AECOPD的效果.方法:收集2021.1-2024.1呼吸内科门诊及住院部收治的96例AECOPD患者,应用随机对照分组原则将所有AECOPD患者分为试验组与对照组,各48例.予以对照组沙丁胺醇气雾剂治疗,予以试验组疏风解毒胶囊联合沙丁胺醇气雾剂治疗.治疗1个月后,对患者进行门诊复查随访,比较其临床疗效,相关评分指标[中医证候积分、CAT、mMRC],肺功能及血气指标[FEV_(1)/FVC、FEV_(1)、PEF、PaCO_(2)、PaO_(2)],炎症因子[PCT、MMP-9、IL-8、MCP-1],最后比较两组安全性.结果:两组总有效率实施组间差异比较发现,试验组总有效率91.11%高于对照组71.11%(P<0.05);两组相关评分指标实施组内与组间差异比较发现,治疗后试验组、对照组中医证候积分、CAT评分、痰液积分均降低,试验组比对照组更低(P<0.05);两组肺功能及血气指标实施组内与组间差异比较发现,治疗后试验组、对照组FEV_(1)/FVC、FEV_(1)、PEF水平均升高,试验组比对照组更高(P<0.05),治疗后试验组、对照组PaCO_(2)、PaO_(2)降低,试验组比对照组更低(P<0.05);两组炎症因子实施组内与组间差异比较发现,治疗后试验组、对照组PCT、MMP-9、IL-8、MCP-1均降低,试验组比对照组更低(P<0.05);两组患者均无严重不良反应发生,两组不良反应发生率比较无明显差异(P>0.05).结论:与沙丁胺醇治疗相比,疏风解毒胶囊联合沙丁胺醇气雾剂治疗AECOPD疗效更优,可改善患者中西医症状,减轻呼吸困难情况,降低痰液粘稠度,改善患者肺功能及通气功能,降低机体炎症反应,且安全性较高.Objective:To analyze the efficacy of Shufeng Jiedu Capsule combined with salbutamol aerosol in the treatment of exacerbation of AECOPD.Methods:Ninety six AECOPD patients admitted to the respiratory department outpatient and inpatient departments in 2021.1-2024.1 were collected.All AECOPD patients were randomly divided into an experimental group and a matched group,with 48 patients in each group,using a randomized controlled grouping principle.The matched group was treated with salbutamol aerosol,while the experimental group was treated with Shufeng Jiedu Capsules combined with salbutamol aerosol.After one month of treatment,the patient underwent outpatient follow-up to compare their clinical efficacy,related scoring indicators[TCM syndrome integral,CAT,mMRC],pulmonary function and blood gas indicators[FEV_(1)/FVC,FEV_(1),PEF,PaCO_(2),PaO_(2)],and inflammatory factors[PCT,MMP-9,IL-8,MCP-1],and finally compare the safety of the two groups.Results:Comparing the differences in total effective rate between the two groups,it was found that the experimental group had a total effective rate of 91.11%,which was higher than the matched group's 71.11%(P<0.05);Comparison of intra group and inter group differences in two related scoring indicators revealed that post-treatment,the TCM syndrome score,CAT score,and sputum score in both the experimental group and the matched group decreased,with the experimental group showing a lower score than the matched group(P<0.05);Comparison of intra-and inter group differences in lung function and blood gas indicators between two groups revealed that post-treatment,the levels of FEV_(1)/FVC,FEV_(1),and PEF increased in both the experimental and matched groups,with the experimental group showing higher levels than the matched group(P<0.05).However,post-treatment,the levels of PaCO_(2) and PaO_(2) decreased in both groups,with the experimental group showing lower levels than the matched group(P<0.05);Comparison of intra-and inter group differences in the implementation of two inflammatory fa

关 键 词：疏风解毒胶囊 沙丁胺醇 慢性阻塞性肺病加重期 炎症因子 中医证候积分 血气指标 肺功能 

分 类 号：R3[医药卫生—基础医学] R563.5