胆石利通片联合腹腔镜胆囊切除术对急性结石性胆囊炎患者的疗效研究  

Curative Effect of Danshitong Tablet Combined with Laparoscopic Cholecystectomy on Patients with Acute Calculous Cholecystitis

作　　者：常素红 张建立 薛芳 栗晓路 CHANG Su-hong;ZHANG Jian-li;XUE Fang;LI Xiao-lu(Department of Surgery,Changzhi Changzi County People's Hospital,Changzhi,Shanxi,046600,China;Department of General Surgery,Changzhi Second People's Hospital,Changzhi,Shanxi,046699,China)

机构地区：[1]长治市长子县人民医院外科,山西长治046600 [2]长治市第二人民医院普外科,山西长治046699

出　　处：《现代生物医学进展》2025年第4期670-676,共7页Progress in Modern Biomedicine

基　　金：长治市科技创新计划项目(0900026)。

摘　　要：目的:探讨急性结石性胆囊炎患者经腹腔镜胆囊切除术后联合胆石利通片治疗的疗效.方法:采用随机数字表法将76例急性结石性胆囊炎患者分为对照组(n=38,腹腔镜胆囊切除术+常规治疗)和研究组(n=38,对照组基础上+胆石利通片治疗).对比两组临床总有效率、围术期指标、炎性介质指标[白细胞介素-8(IL-8)、可溶性血红蛋白清道夫受体(sCD163)、C反应蛋白(CRP)]及不良反应总发生率.结果:研究组的排气时间、排便时间、腹胀缓解时间、进食固体食物时间、住院时间短于对照组,临床总有效率高于对照组(P<0.05).研究组治疗后IL-8、CRP、sCD163低于对照组(P<0.05).两组不良反应总发生率对比未见差异(P>0.05).结论:胆石利通片联合腹腔镜胆囊切除术治疗急性结石性胆囊炎患者,可提高临床总有效率,改善围术期指标,并降低炎症介质水平,安全可靠.Objective:To investigate the curative effect of laparoscopic cholecystectomy combined with Danshitong tablet in patients with acute calculous cholecystitis.Methods:76 patients with acute calculous cholecystitis were divided into control group(n=38,laparoscopic cholecystectom combined with conventional treatment)and study group(n=38,Danshitong tablet on the basis of the control group)according to random number table method.The clinical total effective rate,perioperative indexes,inflammatory mediators[interleukin-8(IL-8),soluble hemoglobin scavenger Receptor(sCD163),c-reactive protein(CRP)]and the total incidence of adverse reactions were compared between the two groups.Results:The evacuation time,defecation time,abdominal distension relief time,eating solid food time,hospitalization time of the study group were shorter than those of the control group,clinical total effective rate was higher than that of the control group(P<0.05).The levels of IL-8,CRP and sCD163 in the study group was lower than those of the control group(P<0.05).There was no difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:Danshitong tablet combined with laparoscopic cholecystectomy in the treatment of patients with acute calculous cholecystitis can improve the clinical total effective rate,improve perioperative indexes,and reduce the level of inflammatory mediators,which is safe and reliable.

关 键 词：胆石利通片 腹腔镜胆囊切除术 急性结石性胆囊炎 炎症介质 疗效 

分 类 号：R3[医药卫生—基础医学] R657.41