血清骨膜素对婴幼儿喘息进展为哮喘的预测价值研究  

Study on the Predictive Value of Serum Periostein in Asthmatic Progression of Infants

作　　者：丁海娟 吴晓凤 樊骅娴 栗福云 张丽 DING Hai-juan;WU Xiao-feng;FAN Hua-xian;LI Fu-yun;ZHANG Li(Department of Pediatrics,Huaian Fifth People's Hospital,Huaian,Jiangsu,223000,China;Department of Laboratory,Huaian Fifth People's Hospital,Huaian,Jiangsu,223000,China)

机构地区：[1]淮安市第五人民医院儿科,江苏淮安223000 [2]淮安市第五人民医院检验科,江苏淮安223000

出　　处：《现代生物医学进展》2025年第4期684-690,共7页Progress in Modern Biomedicine

基　　金：江苏省卫生保健科研课题(BJ22035)。

摘　　要：目的:研究血清骨膜素对婴幼儿喘息进展为哮喘的预测价值研究.方法:前瞻性纳入2022年8月-2024年8月在我院接受治疗的喘息婴幼儿108例,根据1年内是否进展为哮喘分为哮喘组(n=44)和非哮喘组(n=64),比较两组婴幼儿血清骨膜素、一般临床资料及其他实验室指标,并通过多因素分析确定影响喘息婴幼儿进展为哮喘的影响因素.结果:非哮喘组患者在急性期和恢复期血清骨膜素水平均低于哮喘组婴幼儿(P<0.05).恢复期血清骨膜素、母亲过敏、总IgE升高以及嗜酸细胞升高是影响喘息婴幼儿进展为哮喘的独立影响因素.喘息婴幼儿恢复期血清骨膜素预测哮喘的AUC为0.852,其预测喘息婴幼儿进展为哮喘的最佳临界值为109.2µg/L,敏感度为82.50%,特异度为91.67%.结论:喘息婴幼儿恢复期血清骨膜素是影响其进展为哮喘的独立危险因素,并且对喘息婴幼儿是否进展为哮喘具有预测价值.Objective:To study the predictive value of serum periostein in asthmatic progression of infants and young children.Methods:108 asthmatic infants treated in our hospital from August 2022-August 2024 were prospectively included and divided into asthma group(n=44)and non-asthmatic group(n=64)according to whether asthma developed within 1 year.Serum periostein,general clinical data and other laboratory indicators of infants in the two groups were compared.The factors affecting the progression of asthma in asthmatic infants were determined by multi-factor analysis.Results:The serum periostein level of non-asthmatic group was significantly lower than that of asthmatic group in acute and convalescent stages(P<0.05).Serum periostein,maternal hypersensitivity,total IgE and eosinophilic cell increase during convalescence were independent factors affecting the progression of asthma in asthmatic infants.The AUC of serum periostein in asthmatic infants during convalescence was 0.852,and the optimal threshold for predicting asthmatic progression was 109.2μg/L,sensitivity was 82.50%,and specificity was 91.67%.Conclusion:Serum periostein is an independent risk factor for asthmatic progression in convalescent infants and has predictive value for asthmatic progression.

关 键 词：婴幼儿 骨膜素 喘息 哮喘 

分 类 号：R3[医药卫生—基础医学] R725.6