HALP评分、RLR、LAR预测口腔鳞状细胞癌患者预后的临床价值  

Clinical Value of HALP Score,RLR and LAR in Predicting Prognosis of Patients with Oral Squamous Cell Carcinoma

作　　者：许海凤 季炼 陈志飞 候德强 XU Hai-feng;JI Lian;CHEN Zhi-fei;HOU De-qiang(Department of Stomatology,Affiliated Hospital of Jiangnan University,Wuxi,Jiangsu,214101,China)

机构地区：[1]江南大学附属医院口腔科,江苏无锡214101

出　　处：《现代生物医学进展》2025年第4期729-736,共8页Progress in Modern Biomedicine

基　　金：江苏省无锡市卫生健康委员会科研项目(MS201909)。

摘　　要：目的:探讨HALP评分、红细胞体积分布宽度(RDW)/淋巴细胞绝对值(ALC)比值(RLR)、乳酸脱氢酶(LDH)/白蛋白(ALB)(LAR)预测口腔鳞状细胞癌(OSCC)患者预后的临床价值.方法:纳入我院2019年3月~2021年4月期间收治的126例OSCC患者(OSCC组),另选取同期100例体检健康的志愿者(健康对照组).比较健康对照组和OSCC组HALP评分、RLR、LAR.126例OSCC患者随访3年,根据预后情况分为生存组(n=89)和死亡组(n=37).比较不同预后OSCC患者的基线资料,采用Cox回归模型分析OSCC患者预后的影响因素.采用受试者特征(ROC)曲线分析HALP评分、RLR、LAR单独及联合检测预测OSCC患者预后的效能.结果:与健康对照组相比,OSCC组HALP评分更低,RLR、LAR更高(P<0.05).126例OSCC患者随访3年,死亡37例,生存89例,总生存率为70.63%.根据预后情况分为生存组(n=89)和死亡组(n=37).OSCC患者不同预后与年龄、吸烟史、TNM分期、组织学分级、神经周围侵犯、淋巴结转移、HALP评分、RLR、LAR有关(P<0.05).Cox回归模型分析显示,TNM分期Ⅲ~Ⅳ期、组织学分级低分化、HALP评分降低、RLR升高、LAR升高为OSCC患者死亡的危险因素(P<0.05).ROC分析结果显示,HALP评分、RLR、LAR单独及联合预测OSCC患者预后的曲线下面积(AUC)(0.95CI)为0.789(0.707~0.857)、0.737(0.651~0.812)、0.708(0.620~0.785),及0.905(0.840~0.950),三者联合预测OSCC患者预后的效能高于单独检测(Z=2.110、3.215、3.561,P均<0.05).结论:TNM分期Ⅲ~Ⅳ期、组织学分级低分化、HALP评分降低、RLR升高、LAR升高与OSCC患者的预后有关,联合检测HALP评分、RLR、LAR可辅助预测OSCC患者的预后.Objective:To investigate the clinical value of HALP score,RBC volume distribution width(RDW)/absolute lymphocyte(ALC)ratio(RLR),lactate dehydrogenase(LDH)/albumin(ALB)(LAR)in predicting prognosis of patients with oral squamous cell carcinoma(OSCC).Methods:126 patients with OSCC(OSCC group)who were admitted to our hospital from March 2019 to April 2021 were included,and another 100 healthy volunteers(healthy control group)were selected during the same period.HALP scores,RLR and LAR were compared between healthy control group and OSCC group.126 patients with OSCC were followed up for 3 years,they were divided into survival group(n=89)and death group(n=37)according to different prognosis.The baseline data of OSCC patients with different prognosis were compared,and the factors influencing the prognosis of OSCC patients were analyzed by Cox regression model.The efficacy of HALP score,RLR and LAR alone and combination to predict the prognosis of OSCC patients were analyzed by receiver operating characteristic(ROC)curve.Results:Compared with healthy control group,HALP score was lower,RLR and LAR were higher in OSCC group(P<0.05).126 patients with OSCC were followed up for 3 years,37 died and 89 survived,the overall survival rate was 70.63%.According to the prognosis,they were divided into survival group(n=89)and death group(n=37).The different prognosis of OSCC patients was related to age,smoking history,TNM stage,histological grade,perineuronal invasion,lymph node metastasis,HALP score,RLR and LAR(P<0.05).Cox regression model analysis showed that,TNM stages wasⅢtoⅣ,histological grade was poorly differentiated,lower HALP score,higher RLR,and higher LAR were risk factors for death in OSCC patients(P<0.05).ROC analysis results showed that,the area under the curve(AUC)(0.95CI)of HALP score,RLR and LAR alone and combination to predict the prognosis of OSCC patients were 0.789(0.707~0.857),0.737(0.651~0.812)and 0.708(0.620~0.785),and 0.905(0.840-0.950),the combined efficacy of the three tests in predicting the prognosis

关 键 词：HALP评分 RLR LAR 口腔鳞状细胞癌 预后 预测价值 

分 类 号：R3[医药卫生—基础医学] R739.8