醒脑开窍针刺法对肝气郁结型产后抑郁患者抑郁症状、神经内分泌和自噬标志物表达的影响  

Effect of Xingnao Kaiqiao Acupuncture Treatment on Depressive Symptoms,Neuroendocrine and Autophagy Markers Expression in Postpartum Depression Patients with Stagnation of Liver Qi

作　　者：郭琳琳 梁振[1] 汤欣[1] GUO Lin-lin;LIANG Zhen;TANG Xin(Department of Gynaecology and Obstetrics,Xuzhou Central Hospital,Xuzhou,Jiangsu,221000,China)

机构地区：[1]徐州市中心医院妇产科,江苏徐州221000

出　　处：《现代生物医学进展》2025年第4期737-743,751,共8页Progress in Modern Biomedicine

基　　金：徐州市卫生健康委医学科技创新项目(XWKYHT20220093)。

摘　　要：目的:探讨醒脑开窍针刺法对肝气郁结型产后抑郁患者抑郁症状、神经内分泌和自噬标志物表达的影响.方法:采用随机数字表法将我院2022年3月~2024年2月期间收治的肝气郁结型产后抑郁患者(151例)分为实验组(n=76,西医治疗联合醒脑开窍针刺法)、对照组(n=75,西医治疗).对比两组中医疗效以及治疗前后的抑郁相关量表评分、神经内分泌指标、自噬标志物.结果:实验组的临床总有效率高于对照组(P<0.05).两组治疗后汉密尔顿抑郁量表-17项版本(HAMD-17)评分、爱丁堡产后抑郁量表(EPDS)评分、血清自噬降解底物蛋白1(p62)水平、血清皮质醇、促肾上腺皮质激素(ACTH)水平下降,且实验组低于对照组(P<0.05).两组治疗后血清微管相关蛋白轻链3-Ⅱ(LC3-Ⅱ)、自噬基因BECN 1(Beclin1)水平、血清5-羟色胺(5-HT)水平升高,且实验组高于对照组(P<0.05).结论:醒脑开窍针刺法用于肝气郁结型产后抑郁患者,可有效缓解抑郁症状,调节神经内分泌指标和自噬标志物.Objective:To explore effects of Xingnao Kaiqiao acupuncture treatment on depressive symptoms,neuroendocrine and autophagy markers expression in postpartum depression patients with stagnation of liver qi.Methods:Using random number table method,postpartum depression patients with stagnation of liver qi(151 cases)who were admitted to our hospital from March 2022 to February 2024 were divided into experimental group(n=76,western medicine treatment combined with Xingnao Kaiqiao acupuncture treatment)and control group(n=75,western medicine treatment).The therapeutic effects of traditional Chinese medicine,as well as the depression related scale scores,neuroendocrine indicators,and autophagy markers of two groups before and after treatment were compared.Results:The clinical total effective rate of the experimental group was higher than that of the control group(P<0.05).The Hamilton Depression Rating Scale 17(HAMD-17)score,Edinburgh Postnatal Depression Scale(EPDS)score,serum autophagic degradation substrate protein 1(p62)level,serum cortisol,and adrenocorticotropic hormone(ACTH)levels decreased after treatment in both groups,and the experimental group was lower than that of the control group(P<0.05).The levels of serum microtubule associated protein light chain 3-Ⅱ(LC3-Ⅱ),autophagy gene BECN 1(Beclinl),and serum serotonin(5-HT)increased after treatment in both groups,and the experimental group was higher than that of the control group(P<0.05).Conclusion:Xingnao Kaiqiao acupuncture treatment can effectively alleviate depressive symptoms,regulate neuroendocrine indicators and autophagy markers in postpartum depression patients with stagnation of liver qi.

关 键 词：醒脑开窍针刺法 肝气郁结型 产后抑郁 神经内分泌 自噬标志物 

分 类 号：R3[医药卫生—基础医学] R245.31