孕晚期生殖道B族链球菌定植患者血清CAR、PCT/ALB表达及与母婴结局的关系  

Relationship between Serum CAR,PCT/ALB Expression and Maternal and Infant Outcomes in Patients with Reproductive Tract Group B Streptococcus Colonization in Late Pregnancy

作　　者：胡杨 季俊 钱逸郢 李梅 丁邦宇 HU Yang;JI Jun;QIAN Yi-ying;LI Mei;DING Bang-yu(Department of Laboratory,Taixing Maternal and Child Health Hospital,Taixing,Jiangsu,225400,China)

机构地区：[1]泰兴市妇幼保健院检验科,江苏泰兴225400

出　　处：《现代生物医学进展》2025年第4期766-773,共8页Progress in Modern Biomedicine

摘　　要：目的:探讨孕晚期生殖道B族链球菌(GBS)定植患者血清C-反应蛋白/白蛋白比值(CAR)、降钙素原(PCT)/白蛋白(ALB)表达及与母婴结局的关系.方法:选取2022年3月~2024年5月期间泰兴市妇幼保健院收治的96例孕晚期GBS定植患者(观察组),另选取同期96例产检健康的孕妇(对照组),比较两组血清CAR、PCT/ALB水平.根据96例GBS定植患者的母婴结局将其分为妊娠不良组(n=47)和妊娠正常组(n=49),比较两组血清CAR、PCT/ALB水平.采用多因素Logistic回归分析影响因素;采用受试者工作特征(ROC)曲线评估预测价值.结果:观察组的CAR、PCT/ALB高于对照组(P<0.05).妊娠不良组的CAR、PCT/ALB高于妊娠正常组(P<0.05).妊娠不良组和妊娠正常组年龄、流产史或早产史比例、阴道微生态失调比例、白带清洁度、真菌阴/阳性比例、滴虫阴/阳性比例、唾液酸苷酶阴/阳性比例比较差异具有统计学意义(P<0.05).CAR偏高、年龄偏大、唾液酸苷酶阳性、阴道微生态失调、PCT/ALB偏高、白带清洁度Ⅲ~Ⅳ度是GBS定植患者母婴结局不良的危险因素(P<0.05).CAR、PCT/ALB单独及联合预测GBS定植患者母婴结局的曲面下面积(AUC)分别为0.744、0.858、0.910,联合应用预测效能高于单独应用.结论:孕晚期GBS定植患者血清CAR、PCT/ALB呈异常高表达,是其母婴结局不良的危险因素,联合检测CAR、PCT/ALB具有较高的预测价值.Objective:To investigate the relationship between serum C-reactive protein/albumin ratio(CAR),procalcitonin(PCT)/albumin(ALB)expression and maternal and infant outcomes in patients with reproductive tract group B streptococcus(GBS)colonization in late pregnancy.Methods:A total of 96 patients with GBS colonization in late pregnancy who were admitted to Taixing Maternal and Child Health Hospital from March 2022 to May 2024 were selected(observer group),and 96 healthy pregnant women during the same period(control group)were selected,and serum CAR and PCT/ALB levels were compared between the two groups.According to the maternal and in fant outcomes of 96 patients with GBS implantation,they were divided into adverse pregnancy group(n=47)and normal pregnancy group(n=49),and serum CAR and PCT/ALB levels were compared between the two groups.The influencing factors of adverse were analyzed by multivariate logistic regression.The predictive value was evaluated by receiver operating characteristic(ROC)curve.Results:CAR and PCT/ALB in observer group were higher than those in control group(P<0.05).CAR and PCT/ALB in the adverse pregnancy group were higher than those in the normal pregnancy group(P<0.05).There were statistically significant differences between the adverse pregnancy group and the normal pregnancy group in age,history of abortion or premature birth,vaginal microecological imbalance,leucorrhea cleanliness,fungal negative/positive ratio,trichomoniasis negative/positive ratio and sialidase negative/positive ratio(P<0.05).High CAR,older age,sialidase positive,vaginal microecological imbalance,high PCT/ALB and leucorrhea cleanlinessⅢ~Ⅳwere the risk factors for adverse outcomes in GBS patients(P<0.05).The area under surface(AUC)of CAR and PCT/ALB alone and combined to predict maternal and infant outcomes of GBS implantation patients were 0.744,0.858 and 0.910,respectively.The predictive efficacy of combined application was higher than that of single application.Conclusion:The abnormal high CAR and PCT/ALB expressi

关 键 词：孕晚期 生殖道B族链球菌定植 C-反应蛋白/白蛋白比值 降钙素原/白蛋白 母婴结局 

分 类 号：R3[医药卫生—基础医学] R446.11