联合T_(1)-Mapping与T_(2)-Mapping评估慢性肾病肾功能的价值  

Value of the combined T1-mapping and T2-mapping imaging in evaluating renal function in chronic kidney disease

作　　者：李雪松 张庆娟 余玉盛[1] 周清清 张宏[1] LI Xuesong;ZHANG Qingjuan;YU Yusheng;ZHOU Qingqing;ZHANG Hong(Department of Radiology,Jiangning Hospital,Nanjing 210000,China;Department of Nephrology,Jiangning Hospital,Nanjing 210000,China)

机构地区：[1]江苏省南京市江宁医院医学影像科,江苏南京210000 [2]江苏省南京市江宁医院肾内科,江苏南京210000

出　　处：《医学影像学杂志》2025年第2期84-87,99,共5页Journal of Medical Imaging

基　　金：江苏省南京市卫生科技发展专项资金项目(编号:YKK22226)。

摘　　要：目的探讨联合T_(1)-Mapping与T_(2)-Mapping评估慢性肾病(CKD)肾功能的可行性。方法选取CKD患者81例,所有患者均行T_(2)WI、T_(1)-Mapping及T_(2)-Mapping扫描及肾功能生化检查。基于估算肾小球滤过率(eGFR)将患者分为轻、中及重度三组,测量肾脏T_(1)及T_(2)值并比较其组间差异及与eGFR的相关性。结果三组间肾皮质、髓质T_(1)值及髓质T_(2)值差异有统计学意义(F=8.353,9.431,10.090;P<0.05)。肾皮质T_(1)值、髓质T_(1)值及髓质T_(2)与eGFR存在相关性(r=-0.409,-0.389,0.372;P<0.05)。联合肾皮质、髓质T_(1)值及髓质T_(2)值在鉴别轻度与中、重度CKD的诊断效能最佳(AUC=0.869,P<0.001)。结论T_(1)-Mapping与T_(2)-Mapping对CKD肾功能评估具有一定参考价值;联合T_(1)-Mapping与T_(2)-Mapping可提高鉴别轻度与中、重度CKD的诊断效能。Objective To explore the feasibility of combined T_(1)-Mapping and T_(2)-Mapping in assessing renal function in chronic kidney disease(CKD).Methods Eighty-one CKD patients were included,and all patients underwent T_(2)WI,T_(1)-Mapping,and T_(2)-Mapping scans and biochemical tests for renal function.The patients were divided into three groups(mild,moderate,and severe)based on the estimated glomerular filtration rate(eGFR).The renal T_(1) and T_(2) values were measured and the differences between groups and their correlation with eGFR were compared.Results There were differences in renal cortex,medulla T_(1) values,and medulla T_(2) values among the three groups(F=8.353,9.431,10.090;all P<0.05).Renal cortex T_(1) value,medulla T_(1) value,and medulla T_(2) were correlated with eGFR(r=-0.409,-0.389,0.372;all P<0.05).The combined renal cortex,medulla T_(1) values,and medulla T_(2) values showed the best diagnostic efficiency in distinguishing mild from moderate and severe CKD(AUC=0.869,P<0.001).Conclusion T_(1)-Mapping and T_(2)-Mapping have certain reference value for assessing CKD renal function;the combined T_(1)-Mapping and T_(2)-Mapping can improve the diagnostic efficiency of distinguishing mild from moderate and severe CKD.

关 键 词：慢性肾病 肾功能评估 磁共振成像 定量技术 

分 类 号：R692.9[医药卫生—泌尿科学] R445.2[医药卫生—外科学]