重度高胆红素血症新生儿发生急性胆红素脑病的影响因素分析  

Analysis of Influencing Factors of Acute Bilirubin Encephalopathy in Neonates with Severe Hyperbilirubinemia

作　　者：范雅馨 崔彦存 Fan Yaxin;Cui Yancun(Chengde Medical College1,Chengde 067000,Hebei Province,China;Hengshui People's Hospital2,Hengshui 053000,Hebei Province,China)

机构地区：[1]承德医学院,河北承德067000 [2]衡水市人民医院2,河北衡水053000

出　　处：《中外医药研究》2025年第5期27-29,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：目的:探讨重度高胆红素血症新生儿发生急性胆红素脑病(ABE)的影响因素。方法:回顾性收集2020年9月—2023年9月于衡水市人民医院、衡水市第四医院、衡水市第五医院、衡水市妇幼保健院、衡水市桃城区妇幼保健院新生儿科病房住院治疗的205例重度高胆红素血症患儿的临床资料。根据是否合并ABE分为非ABE组(162例)和ABE组(43例)。比较两组的一般资料和病历信息,将单因素分析差异有统计学意义的变量纳入多因素Logistic回归分析。结果:ABE组黄疸发生至入院时间,总胆红素(TBiL)、间接胆红素(IBiL)、总胆红素/白蛋白(B/A)水平,早期喂养不足率高于非ABE组(P<0.05)。多因素Logistic回归分析显示,黄疸发生至入院时间长,TBiL、IBiL、B/A水平高,早期喂养不足是重度高胆红素血症新生儿发生ABE的危险因素(P<0.05)。结论:黄疸发生至入院时间长,TBiL、IBiL、B/A水平高,早期喂养不足是重度高胆红素血症新生儿发生ABE的高危因素。临床应针对高胆红素血症进行早期干预,加强家属新生儿喂养护理知识宣教,鼓励早发现早就诊,预防新生儿ABE。Objective:To investigate the influencing factors of acute bilirubin encephalopathy(ABE)in neonates with severe hyperbilirubinemia.Methods:Clinical data of 205 neonates with severe hyperbilirubinemia admitted to the neonatal wards of Hengshui People's Hospital,Hengshui Fourth Hospital,Hengshui Fifth Hospital,Hengshui Maternal and Child Health Hospital,and Hengshui Taocheng Maternal and Child Health Hospital from September 2020 to September 2023 were retrospectively collected.The patients were divided into a non-ABE group(n=162)and an ABE group(n=43)based on the presence of ABE.General information and medical records of the two groups were compared,and variables with statistically significant differences in univariate analysis were included in multivariate Logistic regression analysis.Results:The time from jaundice onset to admission,levels of total bilirubin(TBiL),indirect bilirubin(IBiL),total bilirubin/albumin ratio(B/A),and the rate of early underfeeding were significantly higher in the ABE group compared to the non-ABE group(P<0.05).Multivariate Logistic regression analysis revealed that a prolonged time from jaundice onset to admission,higher TBiL,IBiL,B/A levels,early underfeeding were independent risk factors for ABE in neonates with severe hyperbilirubinemia(P<0.05).Conclusion:A prolonged time from jaundice onset to admission,higher TBiL,IBiL,B/A levels,and early underfeeding are high-risk factors for ABE in neonates with severe hyperbilirubinemia.Early intervention for hyperbilirubinemia should be implemented in clinical practice,and education on neonatal feeding care should be enhanced to encourage early detection and treatment,thereby preventing neonatal ABE.

关 键 词：重度高胆红素血症 急性胆红素脑病 影响因素 

分 类 号：R722.1[医药卫生—儿科]