大剂量盐酸氨溴索治疗老年慢性阻塞性肺疾病急性加重期患者的效果观察  

Efficacy Observation of High-Dose Ambroxol Hydrochloride in the Treatment of Elderly Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

作　　者：何琴 He Qin(The Second Affiliated Hospital of Guizhou Medical University,Kaili 556000,Guizhou Province,China)

机构地区：[1]贵州医科大学第二附属医院,贵州凯里556000

出　　处：《中外医药研究》2025年第5期33-35,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：目的:观察大剂量盐酸氨溴索治疗老年慢性阻塞性肺疾病急性加重期患者的效果。方法:选取2022年8月—2023年8月于贵州医科大学第二附属医院接受治疗的104例老年慢性阻塞性肺疾病急性加重期患者,随机分为对照组、研究组,各52例。对照组采用常规剂量(30 mg)盐酸氨溴索治疗,研究组采用大剂量(150 mg)盐酸氨溴索治疗。比较两组血气参数、慢性阻塞性肺疾病评估测试评分、症状消失时间、炎性因子水平、疗效。结果:治疗后,两组动脉血氧分压、动脉血氧饱和度水平升高,研究组高于对照组(P<0.05);治疗后,两组慢性阻塞性肺疾病评估测试评分降低,研究组低于对照组(P<0.05);研究组喘息、咳嗽、喘鸣音、湿啰音消失时间短于对照组(P<0.001);治疗后,两组白细胞介素-8与肿瘤坏死因子-α水平降低,研究组低于对照组(P<0.05);研究组治疗总有效率高于对照组(P=0.001)。结论:相比常规剂量盐酸氨溴索,大剂量盐酸氨溴索治疗慢性阻塞性肺疾病急性加重期老年患者的效果较好,可有效缓解患者的临床症状,提高动脉血氧水平,减轻炎性反应。Objective:To observe the efficacy of high-dose ambroxol hydrochloride in the treatment of elderly patients with acute exacerbation of chronic obstructive pulmonary disease(COPD).Methods:A total of 104 elderly patients with acute exacerbation of COPD treated at the Second Affiliated Hospital of Guizhou Medical University from August 2022 to August 2023 were randomly divided into a control group and a study group,with 52 cases in each group.The control group was treated with a conventional dose(30 mg)of ambroxol hydrochloride,while the study group was treated with a high dose(150 mg)of ambroxol hydrochloride.Blood gas parameters,COPD Assessment Test(CAT)scores,symptom resolution time,inflammatory factor levels,and treatment efficacy were compared between the two groups.Results:After treatment,the levels of arterial oxygen partial pressure and arterial oxygen saturation increased in both groups,with higher levels in the study group compared to the control group(P<0.05).The CAT scores decreased in both groups,with lower scores in the study group compared to the control group(P<0.05).The resolution times for wheezing,coughing,wheezing sounds,and moist rales were shorter in the study group than in the control group(P<0.001).After treatment,the levels of interleukin-8 and tumor necrosis factor-αdecreased in both groups,with lower levels in the study group compared to the control group(P<0.05).The total effective rate of treatment was higher in the study group than in the control group(P=0.001).Conclusion:Compared with the conventional dose of ambroxol hydrochloride,high-dose ambroxol hydrochloride demonstrates superior efficacy in treating elderly patients with acute exacerbation of COPD,effectively alleviating clinical symptoms,improving arterial blood oxygen levels,and reducing inflammatory responses.

关 键 词：盐酸氨溴索 慢性阻塞性肺疾病 急性加重期 

分 类 号：R563.9[医药卫生—呼吸系统]