左心耳封堵术在老年非瓣膜性房颤患者中的应用效果  

The Efficacy of Left Atrial Appendage Closure in Elderly Patients with Non-Valvular Atrial Fibrillation

作　　者：杨钦宇 曾安宁[1] 刘军 葛立永 管梦菊 Yang Qinyu;Zeng Anning;Liu Jun;Ge Liyong;Guan Mengju(Second Department of Cardiovascular Medicine,the First Affiliated Hospital of Qiannan National Medical College(People's Hospital of Qiannan Buyi and Miao Autonomous Prefecture),Duyun 558000,Guizhou Province,China)

机构地区：[1]黔南民族医学高等专科学校第一附属医院(黔南布依族苗族自治州人民医院)心血管内二科,贵州都匀558000

出　　处：《中外医药研究》2025年第5期57-59,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

基　　金：黔南民族医学高等专科学校科研基金项目(编号:QNYZ202022)。

摘　　要：目的:探讨左心耳封堵术(LAAC)在老年非瓣膜性房颤(NVAF)患者中应用效果。方法:选取2020年6月—2022年6月在黔南民族医学高等专科学校第一附属医院治疗的100例老年NVAF患者,随机分为对照组(应用导管射频消融术)、观察组(在对照组基础上行LAAC),各50例。对比两组心功能指标、血生化指标、不良事件。结果:术后4个月,两组冠状动脉左前降支、左室舒张末期内径、心房率降低,左室射血分数升高,观察组优于对照组(P<0.05);术后4个月,两组氨基末端脑利钠肽前体、D-二聚体、纤维蛋白原水平降低,观察组低于对照组(P<0.05);观察组不良事件发生率低于对照组(P=0.036)。结论:LAAC在老年NVAF患者中的应用效果显著,能有效改善心功能及血生化指标,降低不良事件发生风险。Objective:To investigate the efficacy of left atrial appendage closure(LAAC)in elderly patients with non-valvular atrial fibrillation(NVAF).Methods:A total of 100 elderly NVAF patients treated at the First Affiliated Hospital of Qiannan National Medical College from June 2020 to June 2022 were randomly divided into a control group(treated with radiofrequency catheter ablation)and an observation group(treated with LAAC in addition to the control group's treatment),with 50 cases in each group.Cardiac function indicators,blood biochemical markers,and adverse events were compared between the two groups.Results:Four months postoperatively,both groups showed reductions in the left anterior descending coronary artery,left ventricular end-diastolic diameter,and atrial rate,as well as an increase in left ventricular ejection fraction,the observation group was better than the control group(P<0.05).Four months postoperatively,levels of N-terminal pro-brain natriuretic peptide,D-dimer,and fibrinogen decreased in both groups,with the observation group showing lower levels than the control group(P<0.05).The incidence of adverse events in the observation group was lower than that in the control group(P=0.036).Conclusion:LAAC demonstrates significant efficacy in elderly NVAF patients,effectively improving cardiac function and blood biochemical markers while reducing the risk of adverse events.

关 键 词：老年 非瓣膜性房颤 左心耳封堵术 脑卒中 

分 类 号：R541.75[医药卫生—心血管疾病]