头孢哌酮钠舒巴坦钠联合阿奇霉素治疗儿童细菌性肺炎的临床效果  

Clinical Efficacy of Cefoperazone Sodium and Sulbactam Sodium Combined with Azithromycin in the Treatment of Pediatric Bacterial Pneumonia

作　　者：裴瑞洁 Pei Ruijie(Weng'an County Hospital of Traditional Chinese Medicine in Qiannan Buyi and Miao Autonomous Prefecture,Qiannan Buyi and Miao Autonomous Prefecture 550400,Guizhou Province,China)

机构地区：[1]黔南布依族苗族自治州瓮安县中医医院,贵州黔南布依族苗族自治州550400

出　　处：《中外医药研究》2025年第5期63-65,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：目的:评估头孢哌酮钠舒巴坦钠联合阿奇霉素治疗儿童细菌性肺炎的临床效果。方法:选取2022年5月—2024年5月瓮安县中医医院收治的细菌性肺炎患儿80例为研究对象,随机分为观察组、对照组,各40例。在对症治疗基础上,对照组采用阿奇霉素治疗,观察组采用头孢哌酮钠舒巴坦钠联合阿奇霉素治疗。比较两组临床疗效、症状恢复时间、炎症指标、不良反应发生率及肺功能。结果:观察组治疗总有效率高于对照组(P=0.007);治疗后,两组白细胞介素-6、C反应蛋白和降钙素原水平降低,观察组较对照组低(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05);治疗后,两组潮气量和第1秒用力呼气容积升高,观察组高于对照组(P<0.05)。结论:头孢哌酮钠舒巴坦钠联合阿奇霉素治疗儿童细菌性肺炎的效果较好,可促进患儿症状恢复,降低炎性因子水平,改善肺功能,安全性较好。Objective:To evaluate the clinical efficacy of cefoperazone sodium and sulbactam sodium combined with azithromycin in the treatment of pediatric bacterial pneumonia.Methods:Eighty children with bacterial pneumonia admitted to Weng'an County Hospital of Traditional Chinese Medicine from May 2022 to May 2024 were selected as the study subjects and randomly divided into an observation group and a control group,with 40 cases in each group.On the basis of symptomatic treatment,the control group was treated with azithromycin,while the observation group was treated with cefoperazone sodium and sulbactam sodium combined with azithromycin.The clinical efficacy,symptom recovery time,inflammatory indicators,incidence of adverse reactions,and lung function were compared between the two groups.Results:The total effective rate in the observation group was higher than that in the control group(P=0.007).After treatment,the levels of interleukin-6,C-reactive protein,and procalcitonin decreased in both groups,with the observation group showing lower levels than the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).After treatment,the tidal volume and forced expiratory volume in the first second increased in both groups,with the observation group showing higher values than the control group(P<0.05).Conclusion:The combination of cefoperazone sodium and sulbactam sodium with azithromycin is effective in the treatment of pediatric bacterial pneumonia,promoting symptom recovery,reducing inflammatory factor levels,improving lung function,and demonstrating good safety.

关 键 词：儿童细菌性肺炎 头孢哌酮钠舒巴坦钠 阿奇霉素 炎症 肺功能 

分 类 号：R725.6[医药卫生—儿科]