甲泼尼龙联合BiPAP治疗重症呼吸衰竭患者的效果  

The Effect of Methylprednisolone Combined with BiPAP Treatment on Patients with Severe Respiratory Failure

作　　者：刘敏 LIU Min(Huangling County People's Hospital,Huangling 727300,China)

机构地区：[1]黄陵县人民医院,陕西黄陵727300

出　　处：《中外医学研究》2025年第7期130-134,共5页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:观察在重症呼吸衰竭的临床治疗中,甲泼尼龙和双水平气道无创正压通气(bi-level non-invasive positive airway pressure,BiPAP)的联合应用效果。方法:选取2022年6月—2023年6月黄陵县人民医院收治的82例重症呼吸衰竭患者,按照随机信封法分为两组,两组均进行常规治疗,对照组(36例)联用BiPAP,观察组(46例)在对照组基础上联用甲泼尼龙,比较两组应用效果。结果:观察组治疗总有效率和肺部第1秒用力呼气容积(forced expiratory volume in the first second,FEV_(1))、用力肺活量(forced vital capacity,FVC)、动脉血氧分压(partial pressure of oxygen,PaO_(2))、动脉血氧饱和度(blood oxygen saturation,SaO_(2))、氧合指数高于对照组,且动脉血二氧化碳分压(arterial carbon dioxide pressure,PaCO_(2))、收缩压、舒张压、心率和肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、降钙素原(procalcitonin,PCT)、C反应蛋白(C-reactive protein,CRP)水平低于对照组,差异有统计学意义(P<0.05),同时两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:在重症呼吸衰竭常规治疗基础上,甲泼尼龙和BiPAP的联合应用能够显著改善患者动脉血气指标,提高其肺功能,并缓解呼吸道炎症反应,治疗安全性和实用性较高。Objective:To observe the combined application effect of Methylprednisolone and bi-level non-invasive positive airway pressure(BiPAP)in the clinical treatment of severe respiratory failure.Method:A total of 82 patients with severe respiratory failure admitted to Huangling County People's Hospital from June 2022 to June 2023 were selected and randomly divided into two groups using the envelope method.Both groups received routine treatment,with the control group(36 cases)received BiPAP and the observation group(46 cases)received Methylprednisolone on the basis of the control group.The application effects of the two groups were compared.Result:The total effective rate,forced expiratory volume in the first second(FEV_(1)),forced vital capacity(FVC),arterial oxygen pressure(PaO_(2)),arterial oxygen saturation(SaO_(2)),and oxygenation index of the observation group were higher than those of the control group,and arterial carbon dioxide pressure(PaCO_(2)),systolic blood pressure,diastolic blood pressure,heart rate,and levels of tumor necrosis factor-α(TNF-α),procalcitonin(PCT),and C-reactive protein(CRP)were lower than those of the control group,the differences were statistically significant(P<0.05).At the same time,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:On the basis of conventional treatment for severe respiratory failure,the combined use of Methylprednisolone and BiPAP can significantly improve arterial blood gas indicators,enhance lung function,and alleviate respiratory inflammation,the treatment is safe and practical.

关 键 词：甲泼尼龙 双水平气道无创正压通气 重症呼吸衰竭 肺功能 动脉血气指标 炎症因子 

分 类 号：R56[医药卫生—呼吸系统]